{"id":"W3037540119","doi":"10.1182/blood.2019004292","title":"Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"RUNX1; Leukemia; Stem cell; Haematopoiesis; Biology; Cancer research; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009224856,0.0002639898,0.0002202745,0.0003759422,0.0001406418,0.0001383485,0.0001238381,0.0002334499,0.001006883],"category_scores_gemma":[0.0001109825,0.0001663854,0.0001994401,0.0002310921,0.0002312021,0.00007019072,0.0001849988,0.0002607427,0.000295272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002133521,"about_ca_system_score_gemma":0.0001184112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006590676,"about_ca_topic_score_gemma":0.001018778,"domain_scores_codex":[0.9999243,0.000008614029,0.000005940362,0.00002266631,0.00002297026,0.00001544298],"domain_scores_gemma":[0.9999491,0.000006186361,0.00001860183,0.00000662694,0.000003989715,0.00001550172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001493175,0.0000122315,0.003727896,0.0000151618,0.00001181971,0.0009054188,0.00004811861,0.0001203215,0.9918846,0.0001452029,0.00007890168,0.002901017],"study_design_scores_gemma":[0.00007646832,0.0005618997,0.1268691,0.00001065162,0.0001068842,0.01745715,0.0001481559,0.002839194,0.842425,0.0006211536,0.00886222,0.00002221028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979746,0.0003999585,0.0008712523,0.00003182851,0.000003891839,0.000008490713,0.0002001487,0.00009298277,0.0004168695],"genre_scores_gemma":[0.9982631,0.0001932043,0.0005764714,0.0000217645,0.000003244594,0.000008891846,0.0002252089,0.00001234067,0.0006957506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006883,"threshold_uncertainty_score":0.003368318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02172580617951951,"score_gpt":0.2808943614331022,"score_spread":0.2591685552535827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}