{"id":"W3037550322","doi":"10.3390/genes11070722","title":"Of Drugs and Trypanosomatids: New Tools and Knowledge to Reduce Bottlenecks in Drug Discovery","year":2020,"lang":"en","type":"review","venue":"Genes","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Drug discovery; Context (archaeology); Trypanosoma cruzi; Drug; Biology; Leishmaniasis; Computational biology; Chagas disease; Leishmania; Trypanosoma brucei; Kinetoplastida; African trypanosomiasis; Drug resistance; Pharmacology; Trypanosomiasis; Bioinformatics; Virology; Protozoal disease; Malaria; Immunology; Computer science; Genetics; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002523721,0.0002714794,0.001363901,0.0002804224,0.00003372032,0.00006648125,0.0001689182,0.0001263314,0.00002690713],"category_scores_gemma":[0.0002364372,0.0002140898,0.0001366955,0.0005656419,0.00009057838,0.0001280755,0.0002791979,0.000236669,0.00003181913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006866136,"about_ca_system_score_gemma":0.001022526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009794488,"about_ca_topic_score_gemma":0.00007776097,"domain_scores_codex":[0.9984818,0.00007818388,0.0005252485,0.0004570869,0.0001867083,0.000270934],"domain_scores_gemma":[0.9987754,0.0002447158,0.0001056848,0.0004077703,0.00004538143,0.0004210522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001415198,0.00004413611,0.00002099702,0.008323276,0.00006134082,0.000005216796,0.0006256428,1.811524e-8,0.000646406,0.0003360178,0.007368125,0.9825547],"study_design_scores_gemma":[0.0003810861,0.0001034339,0.002521683,0.005275858,0.0001505572,0.00005244917,0.0001945235,6.443832e-7,0.0001731682,0.00004053974,0.9909254,0.0001806289],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001941851,0.9936069,0.00001482984,0.001057348,0.00005722049,0.001234877,0.0002120483,0.00002023067,0.001854687],"genre_scores_gemma":[0.0002770231,0.9937932,0.00062385,0.00004680754,0.0002808596,0.0001090152,0.00008395877,0.00003923967,0.004745988],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9835573,"threshold_uncertainty_score":0.8730327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07812780266259448,"score_gpt":0.3913508967783194,"score_spread":0.3132230941157249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}