{"id":"W3037550322","doi":"10.3390/genes11070722","title":"Of Drugs and Trypanosomatids: New Tools and Knowledge to Reduce Bottlenecks in Drug Discovery","year":2020,"lang":"en","type":"review","venue":"Genes","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Drug discovery; Context (archaeology); Trypanosoma cruzi; Drug; Biology; Leishmaniasis; Computational biology; Chagas disease; Leishmania; Trypanosoma brucei; Kinetoplastida; African trypanosomiasis; Drug resistance; Pharmacology; Trypanosomiasis; Bioinformatics; Virology; Protozoal disease; Malaria; Immunology; Computer science; Genetics; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009918597,0.0009054992,0.001113174,0.002797104,0.0002914817,0.001605564,0.0009765732,0.001694551,0.005457975],"category_scores_gemma":[0.0008800514,0.0003304115,0.0005071488,0.002806815,0.0009230839,0.002773378,0.001149003,0.002259432,0.003663876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008681385,"about_ca_system_score_gemma":0.001396078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002591,"about_ca_topic_score_gemma":0.002086445,"domain_scores_codex":[0.9997377,0.00006475655,0.00002832276,0.00004627364,0.00009284772,0.00003008222],"domain_scores_gemma":[0.9995781,0.0002242813,0.00005952943,0.00002028352,0.00007953386,0.00003829835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004217636,0.00005141017,0.00007919185,0.01313177,0.00005614632,0.0001393087,0.00005838577,0.0002958036,0.001678795,0.01582231,0.02088927,0.9477555],"study_design_scores_gemma":[0.00001348004,0.00007304147,0.0002592784,0.002662051,0.00005160812,0.0004404483,0.00004412135,0.00006828188,0.0004672681,0.003581542,0.9923254,0.00001341599],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008871882,0.9975622,0.0002530065,0.0004018824,0.0001689642,0.00000453824,0.00002066489,0.00001266409,0.001487359],"genre_scores_gemma":[0.0009294954,0.9975029,0.0004313017,0.000291325,0.0001256278,0.000008435952,0.0000360515,0.000002578396,0.0006722421],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005457975,"threshold_uncertainty_score":0.01825869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07812780266259448,"score_gpt":0.3913508967783194,"score_spread":0.3132230941157249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}