{"id":"W3037602706","doi":"10.1038/s41467-020-17011-z","title":"Oncolytic virus-derived type I interferon restricts CAR T cell therapy","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Richard M. Schulze Family Foundation; Mayo Foundation for Medical Education and Research; Oncolytics Biotech","keywords":"Chimeric antigen receptor; Oncolytic virus; Interferon; T cell; Tumor microenvironment; Cancer research; Immune system; Immunotherapy; Chemokine; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001996621,0.000215955,0.0002915407,0.0001475904,0.0001219326,0.0005197919,0.0001780274,0.000336677,0.0009063861],"category_scores_gemma":[0.0002185821,0.0001030526,0.0001573756,0.0001018314,0.0003127619,0.0002242061,0.0002644006,0.0006701816,0.0003152703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003166989,"about_ca_system_score_gemma":0.0003626774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004940442,"about_ca_topic_score_gemma":0.0006272999,"domain_scores_codex":[0.99971,0.00006394239,0.00001949489,0.00006113085,0.00007526613,0.00007000263],"domain_scores_gemma":[0.9998655,0.00004232331,0.0000356396,0.00002293595,0.000014528,0.00001900706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001268562,0.0000295318,0.0004136226,0.00003521846,0.000004957671,0.00003978063,0.000021105,0.0002552762,0.9954237,0.0006546698,0.00008550821,0.002909695],"study_design_scores_gemma":[0.00001645321,0.0003500546,0.0008523327,0.000007957762,0.000016175,0.0003598573,0.0000270067,0.0026784,0.9914801,0.0001547494,0.004053703,0.000003170633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745343,0.003120159,0.01682892,0.0001347585,0.00005938761,0.00008121946,0.0001625768,0.0001804746,0.00489824],"genre_scores_gemma":[0.9955058,0.0004327765,0.002919696,0.00003650112,0.0000106289,0.00003242603,0.00006510499,0.00001404051,0.0009829468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009063861,"threshold_uncertainty_score":0.003032148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0890405139596509,"score_gpt":0.3763875587926741,"score_spread":0.2873470448330232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}