{"id":"W3037602706","doi":"10.1038/s41467-020-17011-z","title":"Oncolytic virus-derived type I interferon restricts CAR T cell therapy","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Richard M. Schulze Family Foundation; Mayo Foundation for Medical Education and Research; Oncolytics Biotech","keywords":"Chimeric antigen receptor; Oncolytic virus; Interferon; T cell; Tumor microenvironment; Cancer research; Immune system; Immunotherapy; Chemokine; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143324,0.0001514989,0.0002487092,0.0000964681,0.0001562987,0.00003413647,0.0009458576,0.0002924072,0.0008806304],"category_scores_gemma":[0.0002414219,0.0001346408,0.0001039265,0.0007752174,0.0001410425,0.00005781446,0.0003091965,0.001983849,0.0002566719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000142019,"about_ca_system_score_gemma":0.0002752116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004920772,"about_ca_topic_score_gemma":0.00007221196,"domain_scores_codex":[0.9988284,0.0001861626,0.0002199846,0.0002339469,0.0003036106,0.0002278722],"domain_scores_gemma":[0.9972094,0.0002920576,0.00006514102,0.001893763,0.0003005282,0.0002391334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007386673,0.0003039221,0.0009416303,0.00002145696,0.00008131823,0.000009198031,0.0014308,0.000002300935,0.9650737,0.000241189,0.02230014,0.008855646],"study_design_scores_gemma":[0.001951766,0.001143612,0.004425099,0.00003840919,0.00004404367,0.000008316914,0.0002663682,0.0006692408,0.09232377,0.00003542491,0.8989066,0.0001872805],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.731011,0.05379064,0.00004872809,0.08620369,0.0003563524,0.002227165,0.00003819796,0.0004964817,0.1258278],"genre_scores_gemma":[0.9788935,0.01199631,0.001430625,0.005239621,0.0001676015,0.0000322026,0.000125171,0.00004720157,0.002067791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8766065,"threshold_uncertainty_score":0.9642285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0890405139596509,"score_gpt":0.3763875587926741,"score_spread":0.2873470448330232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}