{"id":"W3037638198","doi":"10.1038/s41598-020-66223-2","title":"NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Acute promyelocytic leukemia; Cancer research; Arsenic trioxide; Cell growth; PI3K/AKT/mTOR pathway; Protein kinase B; Leukemia; Cell; Apoptosis; Gene knockdown; Biology; Medicine; Retinoic acid; Chemistry; Cell culture; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001612152,0.000144857,0.0001499374,0.00003857553,0.0001065475,0.000130656,0.00005170817,0.00009827341,0.00001149768],"category_scores_gemma":[0.00005238071,0.0001111747,0.00003534972,0.0001858675,0.00008329759,0.00001161035,0.00003794271,0.00005638182,0.000002038337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001016142,"about_ca_system_score_gemma":0.0002610494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006536261,"about_ca_topic_score_gemma":0.00002484653,"domain_scores_codex":[0.9986914,0.00003180695,0.000293165,0.0006078335,0.0001990279,0.000176798],"domain_scores_gemma":[0.9994371,0.000003707567,0.0001854541,0.0002182512,0.0000722359,0.00008323876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000719281,0.000097025,0.3338495,0.00005581688,0.00006119423,0.0001923254,0.0009518975,0.00007185934,0.6630658,0.000002701503,0.0007709417,0.0008089566],"study_design_scores_gemma":[0.0008047845,0.0004374439,0.0085008,0.0000176099,0.00006276138,0.00006099352,0.00008224476,0.001058236,0.9871919,0.00007378383,0.001489638,0.0002198525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985678,0.0001475489,0.000283279,0.0001087532,0.0001983269,0.000353442,0.000003675168,0.0000151397,0.0003220154],"genre_scores_gemma":[0.9972672,0.00001878547,0.0001132387,0.00007501648,0.00003838386,0.00004142754,0.0003703938,0.00001363818,0.002061886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3253487,"threshold_uncertainty_score":0.4533571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127054978264718,"score_gpt":0.2302397867954541,"score_spread":0.218969237012807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}