{"id":"W3037638198","doi":"10.1038/s41598-020-66223-2","title":"NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Acute promyelocytic leukemia; Cancer research; Arsenic trioxide; Cell growth; PI3K/AKT/mTOR pathway; Protein kinase B; Leukemia; Cell; Apoptosis; Gene knockdown; Biology; Medicine; Retinoic acid; Chemistry; Cell culture; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002199144,0.0001726484,0.0001602775,0.0003844025,0.0001596563,0.0004282997,0.0001326123,0.0001823391,0.001004864],"category_scores_gemma":[0.0007154949,0.00005809997,0.0001966355,0.0005341445,0.000186456,0.0001524527,0.0002180857,0.0003429138,0.0001630621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002239205,"about_ca_system_score_gemma":0.0001802092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003769272,"about_ca_topic_score_gemma":0.0005083353,"domain_scores_codex":[0.9998139,0.00004526615,0.00002630753,0.00002983126,0.00005940264,0.00002539964],"domain_scores_gemma":[0.9993369,0.00006739807,0.0004210242,0.00003221126,0.00004703097,0.00009535455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006595409,0.0002133125,0.8674746,0.0002107622,0.0002437149,0.001068501,0.0001238949,0.0004587373,0.08669136,0.0002376786,0.0003718557,0.03631011],"study_design_scores_gemma":[0.00002608565,0.0004693492,0.9864417,0.00001426472,0.0001582257,0.001799761,0.00008418416,0.0006543763,0.008204032,0.0001917426,0.001948413,0.000007929269],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967745,0.001687271,0.0004198514,0.00006437524,0.000006916306,0.00001030048,0.0003405835,0.00002024224,0.000675958],"genre_scores_gemma":[0.9988573,0.0003290912,0.0001442815,0.00001666174,0.000006893257,0.000007365794,0.0002816317,0.000002958059,0.0003538683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004864,"threshold_uncertainty_score":0.003361642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127054978264718,"score_gpt":0.2302397867954541,"score_spread":0.218969237012807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}