{"id":"W3037647457","doi":"10.1128/msphere.00480-20","title":"<i>Candida albicans</i> Genetic Background Influences Mean and Heterogeneity of Drug Responses and Genome Stability during Evolution in Fluconazole","year":2020,"lang":"en","type":"article","venue":"mSphere","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Biology; Candida albicans; Drug resistance; Antifungal drug; Fluconazole; Adaptation (eye); Drug; Genetic Fitness; Genetics; Genome; Corpus albicans; Genetic variability; Evolutionary biology; Antifungal; Microbiology; Genotype; Gene; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002676292,0.0001797385,0.0001576971,0.0003815748,0.0002213161,0.0005411982,0.0002119429,0.0002708022,0.001167831],"category_scores_gemma":[0.0007567126,0.0001110943,0.0001280586,0.0003215714,0.0002165899,0.0002200169,0.0003954943,0.0002999693,0.0001540701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003943146,"about_ca_system_score_gemma":0.0002111871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0021789,"about_ca_topic_score_gemma":0.004251693,"domain_scores_codex":[0.999791,0.00005534739,0.00001315475,0.00005148632,0.00005105487,0.00003807196],"domain_scores_gemma":[0.9996716,0.00009778466,0.0001024804,0.00002362134,0.00004258245,0.00006199179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003302237,0.0000492805,0.02415527,0.00004195077,0.00004666064,0.0001239027,0.0001064435,0.001008383,0.9625587,0.0004228776,0.0002816601,0.01087454],"study_design_scores_gemma":[0.00001684025,0.0005537214,0.7938387,0.0000271069,0.00009184727,0.0007934575,0.0003908299,0.01072148,0.188225,0.0005066837,0.004755316,0.00007892038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979639,0.0002727125,0.0005039425,0.00005831611,0.000005654792,0.00000363132,0.0002093555,0.00002748243,0.0009549082],"genre_scores_gemma":[0.9988544,0.0001146096,0.0003419883,0.00003841202,0.000003290291,0.000004541844,0.0001825532,0.00001908333,0.0004410603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0021789,"threshold_uncertainty_score":0.004332423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086180925966321,"score_gpt":0.2324822914192316,"score_spread":0.2216204821595684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}