{"id":"W3037668580","doi":"10.3389/fcell.2020.00520","title":"Multi-Omic Approach to Identify Phenotypic Modifiers Underlying Cerebral Demyelination in X-Linked Adrenoleukodystrophy","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; Stichting Metakids; BC Children's Hospital","keywords":"Adrenoleukodystrophy; Biology; Omics; Metabolome; Phenotype; Transcriptome; Metabolomics; Peroxisomal disorder; Bioinformatics; Genetics; Computational biology; Gene; Peroxisome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001015118,0.000786978,0.0008697713,0.003682079,0.0007288925,0.001132004,0.0004041506,0.000454086,0.001329225],"category_scores_gemma":[0.00137442,0.0001794109,0.001183356,0.002443785,0.000206271,0.0003272422,0.001057571,0.0005441157,0.000340641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003639039,"about_ca_system_score_gemma":0.0006315557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001953013,"about_ca_topic_score_gemma":0.003951211,"domain_scores_codex":[0.9992839,0.0001787515,0.00008114966,0.0002069006,0.0001782663,0.00007117123],"domain_scores_gemma":[0.9993488,0.0002255807,0.0001927585,0.00008588795,0.00008867394,0.00005832457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001173991,0.0004742544,0.4591197,0.001214943,0.002738557,0.002264693,0.0006569736,0.005691234,0.3997726,0.001339163,0.001810221,0.1237437],"study_design_scores_gemma":[0.00003197454,0.0005258658,0.9230813,0.0001282388,0.001028877,0.00224015,0.0006403219,0.02489249,0.03359543,0.00388222,0.009891474,0.00006161261],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9146362,0.00464804,0.0531581,0.0005557257,0.00008231288,0.0002313221,0.02432002,0.0004580142,0.001910306],"genre_scores_gemma":[0.9018462,0.001369348,0.07050769,0.0003960386,0.00007071154,0.0003556047,0.02380547,0.0001450182,0.001503893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003682079,"threshold_uncertainty_score":0.005368471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03020381776273651,"score_gpt":0.2659058100295898,"score_spread":0.2357019922668533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}