{"id":"W3037704724","doi":"10.20892/j.issn.2095-3941.2019.0261","title":"Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling <i>via</i> PHLPP1 in colorectal cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Biology and Medicine","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Protein kinase B; Colorectal cancer; Cancer research; Apoptosis; Viability assay; Heat shock protein; Biology; Cell growth; In vivo; Gene knockdown; Medicine; Cancer; Internal medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004630665,0.0002792669,0.0004588387,0.00005395521,0.0001525394,0.00001041118,0.0001727848,0.0002453936,0.00008627198],"category_scores_gemma":[0.000253619,0.0002228117,0.00003173333,0.0002060549,0.0005340449,0.000008731962,0.0001189805,0.0002746158,6.72773e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004282776,"about_ca_system_score_gemma":0.0001975151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002216868,"about_ca_topic_score_gemma":0.0006589429,"domain_scores_codex":[0.997983,0.0002652405,0.0003460006,0.0007387703,0.0001504289,0.0005165],"domain_scores_gemma":[0.999401,0.00005228603,0.00005565327,0.0001342078,0.0001043705,0.0002524664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009054056,0.00002635349,0.005174131,0.0001092281,0.00006008337,0.00001067456,0.000237626,0.000008342635,0.9858853,0.00003690704,0.0004115811,0.007134339],"study_design_scores_gemma":[0.002902087,0.001123758,0.001895813,0.0002138444,0.00001267317,0.000005846241,0.00006063139,0.0004799646,0.967414,0.00009552795,0.02547437,0.000321501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9188532,0.07430381,0.0002705405,0.005293691,0.0000808642,0.0009427847,0.0000628428,0.00001883885,0.0001733911],"genre_scores_gemma":[0.9940589,0.003796503,0.0001289505,0.000619212,0.0006269533,0.0004789653,0.0000772017,0.00003398196,0.0001793485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07520564,"threshold_uncertainty_score":0.9085996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02084556090190159,"score_gpt":0.3094600895614033,"score_spread":0.2886145286595017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}