{"id":"W3037759747","doi":"10.1371/journal.pone.0234911","title":"Clinical development success rates and social value of pediatric Phase 1 trials in oncology","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Narodowe Centrum Nauki","keywords":"Medicine; Clinical trial; Psychological intervention; Sample size determination; Meta-analysis; Internal medicine; Population; Oncology; Clinical Oncology; MEDLINE; Cancer; Family medicine; Environmental health; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01502781,0.00008542814,0.001256398,0.0000883801,0.00003341936,0.0000070099,0.0001340929,0.000418106,0.000156901],"category_scores_gemma":[0.08946867,0.00007275539,0.00007954345,0.0002508058,0.0002175429,0.00002763641,0.0001727715,0.001345237,0.00002365594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004877535,"about_ca_system_score_gemma":0.00141422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009775249,"about_ca_topic_score_gemma":0.00002056861,"domain_scores_codex":[0.9960799,0.0009729306,0.001704873,0.0003143934,0.0007145202,0.0002133998],"domain_scores_gemma":[0.9643626,0.03455618,0.000344373,0.0001283414,0.0003458809,0.0002626702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005236686,0.01589164,0.9503764,0.002888174,0.0005913051,0.0001313644,0.003086206,2.356093e-7,0.006105532,0.001797111,0.0004326896,0.01346264],"study_design_scores_gemma":[0.1297516,0.02448839,0.7011126,0.00118338,0.003233666,0.000004102544,0.001436783,0.001718634,0.1201995,0.01335013,0.002497931,0.001023292],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777197,0.0002467374,0.00002072794,0.02098925,0.00003193696,0.0005044217,0.000006886907,0.00001466727,0.0004656769],"genre_scores_gemma":[0.9890334,0.001616142,0.006916293,0.001392551,0.0009164247,0.00002574683,0.00001064974,0.00001373265,0.00007508504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2492638,"threshold_uncertainty_score":0.9182011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8474515578111831,"score_gpt":0.6598239766411282,"score_spread":0.1876275811700548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}