{"id":"W3037825755","doi":"10.1158/1557-3265.ovcasymp18-nt-111","title":"Abstract NT-111: THE ANTIPROGESTIN/ANTIGLUCOCORTICOID MIFEPRISTONE AND THE HIV PROTEASE INHIBITOR NELFINAVIR CAUSE ENDOPLASMIC RETICULUM STRESS AND POTENTIATE THE TOXICITY OF PROTEASOME INHIBITION IN HIGH-GRADE SEROUS EPITHELIAL OVARIAN CANCER CELLS","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Unfolded protein response; Nelfinavir; Medicine; Proteasome inhibitor; Antiglucocorticoid; Internal medicine; Mifepristone; Cancer research; Pharmacology; Endoplasmic reticulum; Immunology; Biology; Glucocorticoid receptor; Multiple myeloma; Viral load; Glucocorticoid; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103467,0.000268586,0.0003522696,0.0001309645,0.0001683692,0.0002799682,0.0002041266,0.0003013806,0.001920774],"category_scores_gemma":[0.0001005906,0.00008727035,0.0002788151,0.0001355911,0.000153803,0.0001791508,0.000166486,0.0006376958,0.0004464549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001861975,"about_ca_system_score_gemma":0.0002880424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007539238,"about_ca_topic_score_gemma":0.0010058,"domain_scores_codex":[0.9998816,0.000020831,0.00001707492,0.00002140352,0.0000344046,0.00002462107],"domain_scores_gemma":[0.999946,0.00001010353,0.000009133357,0.000007317598,0.000008208024,0.00001922815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001693146,0.0005457546,0.001308808,0.0002935283,0.0000423353,0.0004918858,0.00004354088,0.0002571428,0.9823261,0.0002252999,0.001417078,0.01135524],"study_design_scores_gemma":[0.000199476,0.003113269,0.01342599,0.00002617818,0.00006083533,0.001348201,0.00008106981,0.001685401,0.9677827,0.00008037275,0.01218452,0.00001199379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870479,0.006504638,0.0008491466,0.0004485491,0.0002933985,0.0000610833,0.0009050306,0.0000934771,0.003796751],"genre_scores_gemma":[0.9927738,0.001458549,0.0008180827,0.0001604449,0.00003181361,0.00004854286,0.001191611,0.000006754479,0.003510466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001920774,"threshold_uncertainty_score":0.00642556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03140910232338638,"score_gpt":0.3539922238987189,"score_spread":0.3225831215753325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}