{"id":"W3037829129","doi":"10.1038/s41409-020-0982-6","title":"Allogeneic haematopoietic stem cell transplantation improves outcome of adults with relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia entering remission following CD19 chimeric antigen receptor T cells","year":2020,"lang":"en","type":"article","venue":"Bone Marrow Transplantation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"","keywords":"Medicine; Haematopoiesis; Stem cell; Transplantation; Acute lymphocytic leukemia; Chimeric antigen receptor; CD19; Philadelphia chromosome; Immunology; Refractory (planetary science); Leukemia; Hematopoietic stem cell transplantation; Acute leukemia; Lymphoblastic Leukemia; Internal medicine; Antigen; Oncology; Cancer research; T cell; Chromosomal translocation; Biology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002412187,0.0005007003,0.0008561468,0.0002671149,0.000145305,0.00003734814,0.0001996877,0.0002459587,0.0002280976],"category_scores_gemma":[0.000006272677,0.0004477722,0.0003308933,0.0005631003,0.0001030683,0.0003410625,0.00001721391,0.0004019329,0.00003532341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003130599,"about_ca_system_score_gemma":0.0002722029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008839978,"about_ca_topic_score_gemma":0.00001262864,"domain_scores_codex":[0.9966057,0.000184981,0.0009500426,0.0007778482,0.0009420859,0.0005393333],"domain_scores_gemma":[0.9985976,0.0001772589,0.000375431,0.0003244019,0.0001357203,0.0003895694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01255214,0.0001488477,0.004306209,0.003439772,0.0003199169,0.0007205501,0.008505928,0.0001934349,0.9677443,0.000001480496,0.00002066537,0.002046761],"study_design_scores_gemma":[0.01045931,0.002428176,0.01257451,0.00171181,0.001088939,0.0002960149,0.0006533224,0.001115764,0.9691077,0.000001643593,0.00005328082,0.0005095305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920622,0.000370177,0.00489818,0.0003293596,0.0002118613,0.001515347,0.0002070223,0.0001536699,0.000252145],"genre_scores_gemma":[0.994417,0.002690686,0.001365938,0.0001667792,0.0001109549,0.00006096344,0.0008174529,0.0001334506,0.0002367747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008268296,"threshold_uncertainty_score":0.9997974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01360999500684993,"score_gpt":0.2478743851934916,"score_spread":0.2342643901866417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}