{"id":"W3037869932","doi":"10.21801/ppcrj.2020.62.2","title":"PAIN trial: phase II, single-center, double-blinded RCT comparing the efficacy of high dose of liposomal bupivacaine and standard bupivacaine periarticular injection in relieving immediate postoperative pain after total knee arthroplasty. Study protocol","year":2020,"lang":"en","type":"article","venue":"Principles and Practice of Clinical Research Journal","topic":"Anesthesia and Pain Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Bupivacaine; Randomized controlled trial; Anesthesia; Surgery; Total knee arthroplasty; Arthroplasty","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01064523,0.005769536,0.009039587,0.001444527,0.001584811,0.003003933,0.003542988,0.006419003,0.02267194],"category_scores_gemma":[0.009374567,0.002327757,0.004179381,0.001393206,0.003398395,0.003021245,0.001426426,0.005255111,0.003992447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001951953,"about_ca_system_score_gemma":0.005680962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001064062,"about_ca_topic_score_gemma":0.001933704,"domain_scores_codex":[0.9946295,0.003095136,0.0004823519,0.0006567115,0.0006279342,0.0005083057],"domain_scores_gemma":[0.9960272,0.001094152,0.00113739,0.0004142568,0.0005241151,0.000802926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9770926,0.009640297,0.0002087328,0.004820346,0.0009843245,0.00004854626,0.00008436553,0.0002996122,0.00126201,0.0002671083,0.001110582,0.004181374],"study_design_scores_gemma":[0.9844679,0.01407056,0.0001772132,0.00009474515,0.0002495198,0.000008526047,0.00001225327,0.0001179124,0.0001054326,0.00007474565,0.0006120148,0.000009285242],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1843128,0.005482248,0.004595537,0.002072715,0.002425901,0.7894183,0.006840728,0.0005339494,0.004317916],"genre_scores_gemma":[0.1663606,0.003415827,0.01026806,0.002602838,0.0008556674,0.8074507,0.001812782,0.00006378548,0.007169761],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02267194,"threshold_uncertainty_score":0.07584518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2179677857475282,"score_gpt":0.4786659149224645,"score_spread":0.2606981291749363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}