{"id":"W3037869932","doi":"10.21801/ppcrj.2020.62.2","title":"PAIN trial: phase II, single-center, double-blinded RCT comparing the efficacy of high dose of liposomal bupivacaine and standard bupivacaine periarticular injection in relieving immediate postoperative pain after total knee arthroplasty. Study protocol","year":2020,"lang":"en","type":"article","venue":"Principles and Practice of Clinical Research Journal","topic":"Anesthesia and Pain Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Bupivacaine; Randomized controlled trial; Anesthesia; Surgery; Total knee arthroplasty; Arthroplasty","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.05097871,0.0002035518,0.0009576723,0.0001920568,0.0002316845,0.00009065642,0.0001206486,0.0001102574,0.00005354022],"category_scores_gemma":[0.04474934,0.000132799,0.0001509885,0.000414399,0.0004287558,0.0003037458,0.0003298108,0.001602478,4.502174e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004169637,"about_ca_system_score_gemma":0.0003246832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006997898,"about_ca_topic_score_gemma":0.00002209702,"domain_scores_codex":[0.9865991,0.009239676,0.002133836,0.0003890742,0.001262175,0.00037615],"domain_scores_gemma":[0.9846067,0.01303518,0.0009344256,0.0002721065,0.0007830626,0.0003685179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8316507,0.01122157,0.1189206,0.0004452622,0.0005287231,0.0004015468,0.00548144,0.000179203,0.0005461579,0.00009835982,0.00007004027,0.03045634],"study_design_scores_gemma":[0.5548405,0.2316167,0.16482,0.001922252,0.0005023209,0.000312512,0.01773535,0.006746875,0.0002345871,0.00006354129,0.02084211,0.0003633058],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612177,0.0001545873,0.0002968239,0.01142188,0.00004088332,0.02680126,0.00000170355,0.000007144236,0.00005803351],"genre_scores_gemma":[0.997112,0.0001552335,0.0007696195,0.0002748026,0.0003771776,0.001266782,0.000002134457,0.00002162749,0.00002057314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2768102,"threshold_uncertainty_score":0.9772171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2179677857475282,"score_gpt":0.4786659149224645,"score_spread":0.2606981291749363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}