{"id":"W3037900099","doi":"10.1016/j.ahj.2020.06.014","title":"Rationale and design of PROACT Xa: A randomized, multicenter, open-label, clinical trial to evaluate the efficacy and safety of apixaban versus warfarin in patients with a mechanical On-X Aortic Heart Valve","year":2020,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; CryoLife","keywords":"Medicine; Apixaban; Warfarin; Atrial fibrillation; Cardiology; Heart valve; Internal medicine; Aortic valve; Surgery; Randomized controlled trial; Vitamin K antagonist; Rivaroxaban","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05226082,0.006324177,0.005637619,0.001708862,0.003039184,0.003830769,0.004491991,0.008750147,0.0215591],"category_scores_gemma":[0.03781299,0.003611278,0.002841445,0.001645054,0.007147237,0.003462239,0.001646331,0.009722937,0.00997907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001961781,"about_ca_system_score_gemma":0.01029778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000660035,"about_ca_topic_score_gemma":0.001350118,"domain_scores_codex":[0.9539521,0.03151176,0.002380383,0.005095753,0.005241032,0.001818974],"domain_scores_gemma":[0.9844853,0.004655832,0.002638975,0.001792896,0.002494118,0.0039329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7806194,0.02038251,0.00755241,0.02169099,0.003039935,0.001350733,0.001102368,0.00285848,0.008005102,0.03288253,0.04030692,0.08020861],"study_design_scores_gemma":[0.8296255,0.05384174,0.00633699,0.003831989,0.001803221,0.0005023651,0.0002207503,0.00430093,0.001933285,0.0125784,0.08476336,0.0002614355],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01417133,0.004802719,0.01121815,0.00697723,0.005687813,0.9464415,0.003480897,0.0003109841,0.006909431],"genre_scores_gemma":[0.04159648,0.001446918,0.02039072,0.009346017,0.001713314,0.9216657,0.001158982,0.00004044805,0.002641329],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05226082,"threshold_uncertainty_score":0.276385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2173470583374484,"score_gpt":0.4340721891125134,"score_spread":0.216725130775065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}