{"id":"W3037951044","doi":"10.1038/s41380-020-0818-1","title":"Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Douglas Mental Health University Institute; McGill University; McGill Genome Centre","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Vetenskapsrådet; Eisai; Hjärnfonden; Royal Swedish Academy of Sciences; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Pfizer; Biogen; BioClinica; UK Dementia Research Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Grey matter; Posterior cingulate; Pathology; Hippocampus; Biomarker; Entorhinal cortex; Alzheimer's disease; Cerebrospinal fluid; Amyloid (mycology); Context (archaeology); Medicine; Atrophy; Amyloid beta; Psychology; Internal medicine; Neuroscience; Cortex (anatomy); White matter; Disease; Magnetic resonance imaging; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001980412,0.000316013,0.0001733064,0.0003878329,0.0001327182,0.0002029575,0.0001156467,0.0001757541,0.0005138664],"category_scores_gemma":[0.0002552604,0.0001853197,0.0001060408,0.0001786547,0.0002213486,0.0001274933,0.0001663965,0.0002522048,0.00007542537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001257827,"about_ca_system_score_gemma":0.00008940976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001269549,"about_ca_topic_score_gemma":0.001714523,"domain_scores_codex":[0.9999253,0.00001893328,0.000006773705,0.00002029449,0.00001521208,0.00001349728],"domain_scores_gemma":[0.9997706,0.00001977294,0.0001185825,0.00001545651,0.00002497527,0.00005057224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004928885,0.0005221045,0.7699857,0.00005451773,0.0002007276,0.0006178076,0.0002261944,0.0001157336,0.2151988,0.00006628834,0.0001408149,0.007942393],"study_design_scores_gemma":[0.00000895837,0.0002421267,0.9970163,0.000001963568,0.0000270685,0.0002997457,0.00003026476,0.00009646764,0.00216069,0.00004117605,0.00007295397,0.000002177598],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997434,0.0001124701,0.00002969972,0.000004940695,0.000001192786,0.000001598765,0.000014747,0.000001520847,0.00009044563],"genre_scores_gemma":[0.9997185,0.00007017742,0.00004846827,0.00000776116,0.000002034545,0.000002193803,0.0000329807,7.553534e-7,0.0001171834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001269549,"threshold_uncertainty_score":0.002524376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641917271005701,"score_gpt":0.2759788979367968,"score_spread":0.2595597252267398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}