{"id":"W3037972267","doi":"10.1002/psb.1848","title":"Making sense of antisense oligonucleotide therapy","year":2020,"lang":"en","type":"article","venue":"Prescriber","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"World Federation of Science Journalists","funders":"","keywords":"Spinal muscular atrophy; Medicine; Antisense therapy; Duchenne muscular dystrophy; Oligonucleotide; Neuromuscular disease; Muscular dystrophy; Disease; Sense (electronics); Bioinformatics; Neuroscience; Internal medicine; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006076112,0.00008417465,0.000189047,0.00003505516,0.00002200699,0.000007083912,0.00005098251,0.00003418375,0.0003383377],"category_scores_gemma":[0.00008697321,0.00007016982,0.0001038647,0.0001400422,0.00006629633,0.00002173945,0.00005260276,0.0001197597,0.00005306431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003775339,"about_ca_system_score_gemma":0.00004201822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001261984,"about_ca_topic_score_gemma":6.397265e-7,"domain_scores_codex":[0.9991767,0.00004736327,0.0001495723,0.0001853893,0.0002576702,0.0001832744],"domain_scores_gemma":[0.9995508,0.0000241904,0.00002976873,0.0002065255,0.00007182577,0.0001169279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001237074,0.0002981461,0.03238271,0.0003259681,0.0002709322,0.0005627591,0.002084403,0.00002513645,0.8892047,0.0004242893,0.01258342,0.06060045],"study_design_scores_gemma":[0.007528534,0.001244049,0.136716,0.0001824363,0.0001391729,0.0002435516,0.0004413944,0.002607322,0.6448821,0.0001994816,0.2054024,0.0004135296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827508,0.00129683,0.0002378685,0.003091773,0.00003014364,0.0003720064,0.000003489486,0.0000420673,0.01217502],"genre_scores_gemma":[0.9960039,0.000429794,0.0007499927,0.002511605,0.00006549861,0.000004646789,0.00000264399,0.00002501048,0.0002068778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2443226,"threshold_uncertainty_score":0.370456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1698099961990399,"score_gpt":0.3588922902539375,"score_spread":0.1890822940548976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}