{"id":"W3037987551","doi":"10.1016/s1470-2045(20)30335-1","title":"Moving gastrointestinal stromal tumours towards truly personalised precision therapy","year":2020,"lang":"en","type":"letter","venue":"The Lancet Oncology","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Novartis Pharmaceuticals Canada","keywords":"PDGFRA; Imatinib; Medicine; Stromal cell; Cancer research; GiST; Stromal tumor; Regorafenib; Tyrosine kinase; Tyrosine-kinase inhibitor; Oncology; Targeted therapy; Cancer; Internal medicine; Bioinformatics; Biology; Colorectal cancer; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005198391,0.0005636974,0.001453287,0.0001328265,0.0001910036,0.00006614892,0.0006799465,0.0001938411,0.0007161513],"category_scores_gemma":[0.0006620552,0.0003388859,0.0004023808,0.0002179425,0.0004011427,0.00004611772,0.0002092402,0.004190844,0.0002936038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006210374,"about_ca_system_score_gemma":0.001243267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001480363,"about_ca_topic_score_gemma":0.000009085177,"domain_scores_codex":[0.9959263,0.0007202492,0.0004428864,0.000714048,0.0009446977,0.00125185],"domain_scores_gemma":[0.9977764,0.0007159959,0.0002961591,0.0006974009,0.0002166815,0.000297388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00419151,0.0001985849,0.00491157,0.0001640774,0.0001793219,0.03170236,0.0001896158,0.000001629726,0.0008868675,0.0000158035,0.9458524,0.01170627],"study_design_scores_gemma":[0.01336802,0.02894579,0.03901725,0.001089295,0.0004027831,0.03923615,0.0002627047,0.0003607858,0.0003394167,0.0006728718,0.8757616,0.0005433567],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03897725,0.0004219021,0.0001025382,0.9506703,0.0001954865,0.001238448,0.0001270804,0.0002081062,0.008058907],"genre_scores_gemma":[0.08295721,0.0002835988,0.01793458,0.8696587,0.02442047,0.0003500376,0.00093928,0.0002183753,0.003237759],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.08101158,"threshold_uncertainty_score":0.9999063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1047025115265199,"score_gpt":0.3630308298079164,"score_spread":0.2583283182813965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}