{"id":"W3038019203","doi":"10.1128/aac.00152-20","title":"Antileishmanial Aminopyrazoles: Studies into Mechanisms and Stability of Experimental Drug Resistance","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Global Health Innovative Technology Fund; Universiteit Antwerpen; Fonds Wetenschappelijk Onderzoek; Canada Research Chairs; Government of Canada; Ministerie van Buitenlandse Zaken; World Health Organization; Bundesministerium für Bildung und Forschung; Bill and Melinda Gates Foundation","keywords":"Efflux; Drug resistance; Biology; Amastigote; Pharmacology; In vivo; Mefloquine; Leishmania; Genetics; Immunology; Chloroquine; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003292509,0.0002135285,0.0002383787,0.000346796,0.0001491739,0.0002127258,0.0001787534,0.0002539059,0.001804441],"category_scores_gemma":[0.0004235725,0.0001066341,0.0002454245,0.0002333527,0.0002548654,0.0002546837,0.0001377833,0.0005574606,0.0002177266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002244741,"about_ca_system_score_gemma":0.00009045342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005061761,"about_ca_topic_score_gemma":0.0006310579,"domain_scores_codex":[0.9997074,0.00009069077,0.00003481259,0.00005898222,0.00005849549,0.00004954269],"domain_scores_gemma":[0.9995646,0.000143447,0.0001195249,0.00008187014,0.00004593624,0.00004460393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001983091,0.0001049642,0.001047916,0.00003436565,0.00001383071,0.00003528642,0.00003293221,0.00005139145,0.996089,0.00008498089,0.00002367363,0.002283402],"study_design_scores_gemma":[0.00001878607,0.003932825,0.02880611,0.00001031568,0.00005092247,0.0005376739,0.00004074521,0.0008371396,0.9643707,0.00005385944,0.001330126,0.00001093104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961622,0.00135343,0.001410406,0.00003692284,0.0000106818,0.00002571216,0.0002678871,0.00002735089,0.0007054287],"genre_scores_gemma":[0.9960279,0.0008492744,0.001118318,0.00002729873,0.000009080199,0.00003466617,0.000596142,0.0000153384,0.001321991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001804441,"threshold_uncertainty_score":0.00603646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03909598289033615,"score_gpt":0.3172424939556014,"score_spread":0.2781465110652653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}