{"id":"W3038019203","doi":"10.1128/aac.00152-20","title":"Antileishmanial Aminopyrazoles: Studies into Mechanisms and Stability of Experimental Drug Resistance","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Global Health Innovative Technology Fund; Universiteit Antwerpen; Fonds Wetenschappelijk Onderzoek; Canada Research Chairs; Government of Canada; Ministerie van Buitenlandse Zaken; World Health Organization; Bundesministerium für Bildung und Forschung; Bill and Melinda Gates Foundation","keywords":"Efflux; Drug resistance; Biology; Amastigote; Pharmacology; In vivo; Mefloquine; Leishmania; Genetics; Immunology; Chloroquine; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451559,0.0002089712,0.0005540084,0.00003911437,0.0001422549,0.00002238528,0.0000861832,0.00004783587,0.00007343388],"category_scores_gemma":[0.00004471201,0.0001722084,0.000070248,0.0001195829,0.000477458,0.00009843344,0.0001444111,0.0001175728,0.00000229646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003267766,"about_ca_system_score_gemma":0.00002893152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000311085,"about_ca_topic_score_gemma":0.00001779603,"domain_scores_codex":[0.9987652,0.0000387701,0.000307724,0.0004196515,0.0002365972,0.0002320237],"domain_scores_gemma":[0.9994428,0.00003733916,0.00009453438,0.0001633238,0.0001211628,0.0001408709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001262727,0.000330768,0.01874507,0.0008670671,0.0004401623,0.00002726165,0.02244807,3.924511e-8,0.9252225,0.0002375529,0.02941261,0.001006139],"study_design_scores_gemma":[0.003459413,0.0003322283,0.01517725,0.0001779084,0.00004642166,0.000006952556,0.005409343,0.0000249143,0.9698319,0.00009468127,0.005220991,0.0002179561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833406,0.001102952,0.00003643583,0.01481741,0.00004754325,0.0004334467,0.00001175415,0.00003456237,0.0001753038],"genre_scores_gemma":[0.9873006,0.005591223,0.001934638,0.004952444,0.00007628088,0.000007864003,0.000004471689,0.0000254285,0.0001070553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0446094,"threshold_uncertainty_score":0.7022454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03909598289033615,"score_gpt":0.3172424939556014,"score_spread":0.2781465110652653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}