{"id":"W3038037645","doi":"10.3389/fmicb.2020.01440","title":"Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus","year":2020,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Peking Union Medical College; National Natural Science Foundation of China","keywords":"Virology; Biology; RNA; RNA-dependent RNA polymerase; RNA polymerase; Murine norovirus; Polymerase; Dengue virus; Norovirus; Allosteric regulation; Hepatitis C virus; Virus; Enzyme; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001459806,0.0004002269,0.0005762401,0.0002259039,0.0001285064,0.0003239163,0.0003320229,0.0002493112,0.000945697],"category_scores_gemma":[0.0001079194,0.0001464021,0.0003555565,0.0001761657,0.0001314508,0.0001717213,0.0002041243,0.0005702847,0.0002316237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002944809,"about_ca_system_score_gemma":0.0003752176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000508893,"about_ca_topic_score_gemma":0.001530494,"domain_scores_codex":[0.9999374,0.000006981229,0.000005362964,0.00001494995,0.0000174261,0.0000178451],"domain_scores_gemma":[0.9999651,0.000004856271,0.000009027207,0.000002824489,0.000006954085,0.000011244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003344163,0.0002669719,0.0009275956,0.0002944864,0.00006100674,0.0002783473,0.000029934,0.002268187,0.9744213,0.0006298873,0.0003551313,0.02013274],"study_design_scores_gemma":[0.0007347179,0.005700467,0.008463074,0.00006807708,0.0003872341,0.002244953,0.00005863212,0.01665817,0.9487013,0.0002729086,0.01665149,0.00005891192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703935,0.01063413,0.01146419,0.0002511305,0.00008661662,0.0003230698,0.0008487285,0.0002000129,0.005798607],"genre_scores_gemma":[0.9834088,0.004371689,0.007927404,0.0001935373,0.00001782608,0.0001086111,0.001287159,0.00001322308,0.002671775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000945697,"threshold_uncertainty_score":0.003163636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007025535087583018,"score_gpt":0.2232008329182597,"score_spread":0.2161752978306766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}