{"id":"W3038059133","doi":"10.1158/1541-7786.mcr-20-0088","title":"Elevated V–ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University; McGill University Health Centre","funders":"Government of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"PTEN; Cancer research; PI3K/AKT/mTOR pathway; mTORC1; Protein kinase B; Signal transduction; Biology; Downregulation and upregulation; Cancer; Carcinogenesis; Breast cancer; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006161465,0.0002818833,0.0003608585,0.0001519358,0.0002181402,0.00008643726,0.0005804594,0.0002642321,0.0001704413],"category_scores_gemma":[0.0002273282,0.0002912441,0.0003242535,0.0008566298,0.0001496003,0.00001982178,0.000370771,0.0004892451,0.00001675208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002086276,"about_ca_system_score_gemma":0.0009199374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001135768,"about_ca_topic_score_gemma":0.0001267581,"domain_scores_codex":[0.9963212,0.0003482641,0.0003122388,0.001048932,0.0008139818,0.001155354],"domain_scores_gemma":[0.998639,0.00006328813,0.00006896858,0.0004674693,0.0003813574,0.0003798771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001607992,0.00009170571,0.001094389,0.0001217513,0.0002152545,0.000128133,0.000150787,0.0003073348,0.9851162,0.000006469519,0.0009562409,0.01020368],"study_design_scores_gemma":[0.001917541,0.0002101248,0.0002095159,0.0001021085,0.00002238503,0.000001476547,0.00008611204,0.001000045,0.9929953,0.00004132384,0.00307431,0.0003397402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854277,0.002130878,0.003968812,0.006870267,0.00006904842,0.0009985305,0.0004261489,0.0000234738,0.00008513049],"genre_scores_gemma":[0.996325,0.000766239,0.0001523727,0.0009439066,0.0003767464,0.001050403,0.00007942285,0.00009905433,0.0002068556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01089729,"threshold_uncertainty_score":0.999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06294300939383339,"score_gpt":0.4078391788391622,"score_spread":0.3448961694453287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}