{"id":"W3038077749","doi":"10.3390/cells9061541","title":"Early Onset of Sex-Dependent Mitochondrial Deficits in the Cortex of 3xTg Alzheimer’s Mice","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Alzheimer's Society; University of Manitoba; Research Manitoba","keywords":"Hippocampus; MFN2; Cortex (anatomy); Cerebral cortex; Neuroscience; Mitochondrion; Biology; Internal medicine; Medicine; Mitochondrial DNA; mitochondrial fusion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003905983,0.0009945584,0.0006287202,0.001978774,0.0004574882,0.0005728755,0.0005676226,0.001023415,0.003997636],"category_scores_gemma":[0.0002564048,0.0004563078,0.0007404474,0.0004255496,0.0007388628,0.0005679103,0.0005668222,0.001526166,0.0008092055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005486654,"about_ca_system_score_gemma":0.0003773466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001804877,"about_ca_topic_score_gemma":0.003051075,"domain_scores_codex":[0.9995763,0.00003263939,0.00006375616,0.0001606599,0.00009758903,0.0000691196],"domain_scores_gemma":[0.9991548,0.00006555653,0.0004171188,0.00006160105,0.00007239747,0.00022853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00045131,0.00009226725,0.0008304571,0.00004709647,0.00001909022,0.0002964215,0.0001154515,0.00004654934,0.9964328,0.0001810106,0.00008572306,0.001401858],"study_design_scores_gemma":[0.0001586798,0.001102725,0.07437546,0.00008284557,0.0001367643,0.002498592,0.0004105474,0.0009470723,0.9140363,0.0006360117,0.005553652,0.00006133167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884962,0.00143794,0.003353195,0.0002847939,0.0001075172,0.00005383084,0.004701337,0.0002374929,0.001327697],"genre_scores_gemma":[0.9729523,0.002034143,0.004837532,0.000340717,0.00004458027,0.0002937851,0.00367033,0.0003868133,0.01543979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003997636,"threshold_uncertainty_score":0.01337337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02275279162788306,"score_gpt":0.2452484626590277,"score_spread":0.2224956710311446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}