{"id":"W3038077749","doi":"10.3390/cells9061541","title":"Early Onset of Sex-Dependent Mitochondrial Deficits in the Cortex of 3xTg Alzheimer’s Mice","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Alzheimer's Society; University of Manitoba; Research Manitoba","keywords":"Hippocampus; MFN2; Cortex (anatomy); Cerebral cortex; Neuroscience; Mitochondrion; Biology; Internal medicine; Medicine; Mitochondrial DNA; mitochondrial fusion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000887274,0.00009738778,0.0001654983,0.00002250318,0.00001570187,0.000004943964,0.0002295716,0.0001365302,0.00006826963],"category_scores_gemma":[0.00004525363,0.00007840017,0.0000816385,0.00008254225,0.00006337423,0.000001581566,0.00005173211,0.0000988248,0.00002492356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001749537,"about_ca_system_score_gemma":0.00004542152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003955546,"about_ca_topic_score_gemma":0.00002556656,"domain_scores_codex":[0.9991284,0.0001439109,0.0002599437,0.0002247133,0.0001150014,0.0001280372],"domain_scores_gemma":[0.999554,0.00002934491,0.0001066392,0.0002260985,0.00004199532,0.00004195785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000245935,0.00004638529,0.000737572,0.00001154118,0.00002584464,0.000006544635,0.0006300012,0.00002834577,0.9952856,0.0000224796,0.002788415,0.0001712909],"study_design_scores_gemma":[0.000787145,0.0005504214,0.001090512,0.000004777037,0.00003610794,0.00001014535,0.000302216,0.00001388769,0.9886923,0.00001527891,0.008399754,0.00009749145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964898,0.0003986478,0.0004515468,0.0001689212,0.0004955979,0.0002419141,0.0000738206,0.000003533195,0.001676241],"genre_scores_gemma":[0.998513,0.00004432659,0.0003163621,0.0006639141,0.0002190675,0.000007453993,0.00003475112,0.000009875123,0.0001912715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006593382,"threshold_uncertainty_score":0.3197066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02275279162788306,"score_gpt":0.2452484626590277,"score_spread":0.2224956710311446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}