{"id":"W3038097601","doi":"10.1016/j.mrrev.2020.108318","title":"Reprint of: Deciphering and simulating models of radiation genotoxicity with CRISPR/Cas9 systems","year":2020,"lang":"en","type":"article","venue":"Mutation Research/Reviews in Mutation Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"CANDU Owners Group; Bruce Power","keywords":"CRISPR; Cas9; Radiobiology; Context (archaeology); Computational biology; Biology; Mitophagy; DNA; Computer science; Genetics; Physics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162147,0.0006564829,0.0003994183,0.0004489043,0.00028895,0.0006557029,0.0009930241,0.00155177,0.1096978],"category_scores_gemma":[0.001387136,0.0002383421,0.0005267745,0.0005873871,0.0004388966,0.0008778818,0.0003896395,0.001110186,0.01589996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004057756,"about_ca_system_score_gemma":0.0003085401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002034246,"about_ca_topic_score_gemma":0.003213224,"domain_scores_codex":[0.9999028,0.00001593007,0.000007045624,0.00001728126,0.00004907508,0.000007760185],"domain_scores_gemma":[0.9996301,0.0002037167,0.00002546992,0.00005556524,0.0000572397,0.00002786553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001975557,0.00005763889,0.000353775,0.000663232,0.00004311867,0.0005980889,0.00009073215,0.1105182,0.0112304,0.0933129,0.7176343,0.06530003],"study_design_scores_gemma":[0.0001644873,0.00009715855,0.0008552591,0.00007638377,0.00002512134,0.000439807,0.00006039055,0.2546082,0.007421792,0.08214147,0.6540584,0.00005142896],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.0216477,0.006072809,0.31371,0.03541134,0.07272834,0.0003593453,0.02972445,0.009658026,0.5106879],"genre_scores_gemma":[0.1759358,0.005973487,0.1031455,0.005532642,0.006609857,0.0003162353,0.008459721,0.003590023,0.6904367],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.1096978,"threshold_uncertainty_score":0.3669757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1432539127526758,"score_gpt":0.4585285043014394,"score_spread":0.3152745915487636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}