{"id":"W3038097601","doi":"10.1016/j.mrrev.2020.108318","title":"Reprint of: Deciphering and simulating models of radiation genotoxicity with CRISPR/Cas9 systems","year":2020,"lang":"en","type":"article","venue":"Mutation Research/Reviews in Mutation Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"CANDU Owners Group; Bruce Power","keywords":"CRISPR; Cas9; Radiobiology; Context (archaeology); Computational biology; Biology; Mitophagy; DNA; Computer science; Genetics; Physics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004205481,0.0001224661,0.0002840755,0.0002277635,0.00009260662,0.00004116945,0.0001778125,0.0001024278,0.000009102748],"category_scores_gemma":[0.00154924,0.0001144719,0.000046849,0.000839851,0.0001693595,0.00002281945,0.0001455654,0.000323244,0.000002737635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004350715,"about_ca_system_score_gemma":0.0001347619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000205156,"about_ca_topic_score_gemma":0.00003985499,"domain_scores_codex":[0.997148,0.0007484205,0.000640328,0.0004381499,0.0006963051,0.0003287388],"domain_scores_gemma":[0.9985588,0.0002547909,0.0001382121,0.0002721519,0.0006471084,0.0001288883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001908662,0.00005328281,0.002778309,0.001539435,0.00003467837,0.00001030081,0.003013204,0.700986,0.24563,0.0003616825,0.00008039125,0.04532187],"study_design_scores_gemma":[0.001250946,0.00083787,0.00500397,0.0004357143,0.000009556846,0.00001177745,0.0030513,0.7335449,0.2541411,0.0002743827,0.001205314,0.0002330738],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.847235,0.007557682,0.1434525,0.0001414876,0.00001772884,0.001309293,0.000007363798,0.00000709706,0.0002718277],"genre_scores_gemma":[0.9937175,0.002216779,0.003767394,0.00001290741,0.00006146352,0.0001393602,0.00003903674,0.00002378405,0.00002178054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1464825,"threshold_uncertainty_score":0.4668029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1432539127526758,"score_gpt":0.4585285043014394,"score_spread":0.3152745915487636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}