{"id":"W3038109636","doi":"10.4049/jimmunol.1900811","title":"CTL Clonotypes with Higher TCR Affinity Have Better Ability to Reduce the HIV Latent Reservoir","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"U.S. Army","keywords":"CTL*; T-cell receptor; CD8; Biology; Cytotoxic T cell; Immunology; Ex vivo; Immune system; Peripheral blood mononuclear cell; Effector; Latency (audio); Virology; In vivo; T cell; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082952,0.0001985981,0.0002249258,0.0001306298,0.00009158828,0.0002619714,0.000103299,0.0002064973,0.0027718],"category_scores_gemma":[0.0001761197,0.00008075089,0.0001345806,0.0000859014,0.00007827978,0.0001163317,0.0001487322,0.0004277209,0.0004579236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001005628,"about_ca_system_score_gemma":0.0001043914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001871209,"about_ca_topic_score_gemma":0.0001950672,"domain_scores_codex":[0.999879,0.00002448402,0.000008945602,0.00001791118,0.00001803726,0.00005161499],"domain_scores_gemma":[0.9998281,0.00006253625,0.0000223994,0.00002326172,0.00002778832,0.00003591751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002046016,0.0000770367,0.001236608,0.00002229942,0.000005425155,0.00002700384,0.00001650353,0.00006094389,0.99571,0.00003383812,0.0000293061,0.002576401],"study_design_scores_gemma":[0.0000770005,0.002775732,0.0342123,0.00001531796,0.00007860033,0.001463746,0.00007960083,0.001503613,0.9573935,0.0001029924,0.002287369,0.00001018199],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981578,0.0002847769,0.001032559,0.0000205667,0.000005694611,0.000009779747,0.00005287916,0.00001920865,0.0004166469],"genre_scores_gemma":[0.9983087,0.0001012009,0.0005697294,0.00003754146,0.00000654212,0.00000791811,0.0001296617,0.000008966055,0.0008297642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0027718,"threshold_uncertainty_score":0.009272575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03034571695376426,"score_gpt":0.2676833702498911,"score_spread":0.2373376532961269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}