{"id":"W3038115149","doi":"10.1097/md.0000000000020458","title":"Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition","year":2020,"lang":"en","type":"article","venue":"Medicine","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"NIHR Newcastle Biomedical Research Centre; Newcastle University; National Institute for Health and Care Research; Newcastle upon Tyne Hospitals NHS Foundation Trust; Medical Research Council; Versus Arthritis; Celgene; Gilead Sciences; University of Birmingham; Sanofi; University Hospitals Birmingham NHS Foundation Trust; Pfizer; Birmingham Biomedical Research Centre; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Tolerability; Rheumatoid arthritis; Internal medicine; Oncology; Adverse effect; Pharmacodynamics; Clinical endpoint; Arthritis; Clinical trial; Pharmacology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007943761,0.0003965433,0.0004006359,0.0002775807,0.0001324248,0.0004618772,0.0002787989,0.0002132077,0.001978057],"category_scores_gemma":[0.000441798,0.0001236188,0.0003710388,0.0002006537,0.0003073771,0.0001591723,0.0001418952,0.0006110802,0.0003469721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006753696,"about_ca_system_score_gemma":0.0007991989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007075675,"about_ca_topic_score_gemma":0.001988055,"domain_scores_codex":[0.9997708,0.00007314157,0.00001251622,0.00005112068,0.00006514317,0.00002726845],"domain_scores_gemma":[0.9998314,0.0000586834,0.0000540016,0.00001713357,0.00001959883,0.00001922811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01372716,0.002308972,0.006890801,0.001967187,0.000361285,0.0001775085,0.00008689125,0.0103944,0.6549758,0.002586368,0.002450388,0.3040732],"study_design_scores_gemma":[0.02182308,0.06351461,0.03190218,0.0003129265,0.0009792303,0.002349457,0.0001060594,0.03235599,0.7828895,0.003368871,0.06030004,0.00009803678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9235129,0.03694059,0.02398944,0.0009159261,0.0001277574,0.001791044,0.001219859,0.0003118464,0.01119069],"genre_scores_gemma":[0.9838145,0.004478778,0.008838912,0.0001405116,0.00004541818,0.0003798477,0.0003138583,0.00001081391,0.00197732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001978057,"threshold_uncertainty_score":0.006617308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134532541352023,"score_gpt":0.252586854370478,"score_spread":0.2391336002352757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}