{"id":"W3038147181","doi":"10.1186/s13023-020-01450-4","title":"Inhaled granulocyte-macrophage colony stimulating factor for mild-to-moderate autoimmune pulmonary alveolar proteinosis - a six month phase II randomized study with 24 months of follow-up","year":2020,"lang":"en","type":"article","venue":"Orphanet Journal of Rare Diseases","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Key Research and Development Program of China; Chinese Academy of Medical Sciences; National Natural Science Foundation of China","keywords":"Pulmonary alveolar proteinosis; Granulocyte macrophage colony-stimulating factor; Medicine; Granulocyte; Immunology; Alveolar macrophage; Granulocyte macrophage colony-stimulating factor receptor; Macrophage; Granulocyte colony-stimulating factor; Internal medicine; Lung; Cytokine; Macrophage colony-stimulating factor; Biology; In vitro; Chemotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0027652,0.001687839,0.004490663,0.0005565727,0.0005823236,0.001195234,0.001130236,0.002194473,0.003849332],"category_scores_gemma":[0.001626715,0.0006992446,0.002058897,0.0005975306,0.001544872,0.0009558161,0.0004827144,0.002486429,0.0008557127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005642207,"about_ca_system_score_gemma":0.001340081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006436108,"about_ca_topic_score_gemma":0.001117663,"domain_scores_codex":[0.9989944,0.0004941064,0.00006546567,0.0001622384,0.0000961452,0.0001876549],"domain_scores_gemma":[0.9985292,0.0002735389,0.0003174257,0.0001851747,0.0001314442,0.0005631358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9683304,0.01931149,0.0007845611,0.0003018618,0.0005303748,0.00003266141,0.00003238447,0.000167692,0.003610296,0.00003708084,0.0002487747,0.006612337],"study_design_scores_gemma":[0.8542402,0.1429975,0.001848849,0.00001266113,0.0002061602,0.0000234584,0.00001212281,0.000112178,0.0003092939,0.00003890591,0.0001907583,0.000007907736],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900771,0.00285207,0.0006510048,0.0003599998,0.0003775875,0.004277877,0.0006655155,0.00007303782,0.000665794],"genre_scores_gemma":[0.9807975,0.002448796,0.002267932,0.001157532,0.0007635001,0.009081712,0.00118089,0.00002572263,0.00227643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004490663,"threshold_uncertainty_score":0.01462394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04139816524429516,"score_gpt":0.3475751092216764,"score_spread":0.3061769439773812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}