{"id":"W3038217579","doi":"10.3390/cells9071593","title":"DNA Damage- But Not Enzalutamide-Induced Senescence in Prostate Cancer Promotes Senolytic Bcl-xL Inhibitor Sensitivity","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Cancer Research Society","keywords":"Senescence; Enzalutamide; DNA damage; Context (archaeology); Biology; Cancer research; Cancer; Prostate cancer; Cancer cell; Cell biology; Genetics; DNA; Androgen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001245495,0.0002523876,0.0002313751,0.0002342247,0.0001234176,0.0002361108,0.0001306457,0.000153757,0.001315776],"category_scores_gemma":[0.0000937967,0.0001178688,0.0002150568,0.0001550002,0.0001223098,0.0001780191,0.0001279787,0.0005180807,0.0002967329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001763105,"about_ca_system_score_gemma":0.0001979323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004034337,"about_ca_topic_score_gemma":0.000863081,"domain_scores_codex":[0.9999084,0.00002225464,0.00001113346,0.00001586899,0.00001908584,0.0000232936],"domain_scores_gemma":[0.9999163,0.00001707136,0.00001695676,0.00001386835,0.00001050686,0.00002534983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001802257,0.00005848315,0.0001434907,0.00003845879,0.000005430311,0.00003195929,0.00001015291,0.00004973888,0.9977682,0.00004165139,0.00003989487,0.001632346],"study_design_scores_gemma":[0.00002562915,0.001121974,0.00529173,0.000005570263,0.00001402443,0.0002869845,0.00001738775,0.0004027675,0.9908298,0.00002554772,0.001974058,0.000004513467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937506,0.003037074,0.001154103,0.00006559325,0.00001997976,0.00003671575,0.0003171212,0.0001078202,0.00151088],"genre_scores_gemma":[0.9961998,0.001025718,0.0007367927,0.00004215713,0.000005078914,0.00003088261,0.0004897057,0.00001470227,0.001455099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315776,"threshold_uncertainty_score":0.004401684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914149946468796,"score_gpt":0.2465029192449439,"score_spread":0.227361419780256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}