{"id":"W3038254578","doi":"10.1002/cpdd.822","title":"Effect of Itraconazole, a Potent CYP3A4 Inhibitor, on the Steady‐State Pharmacokinetics of Vemurafenib in Patients With <i>BRAF</i><sup>V600</sup> Mutation–Positive Malignancies","year":2020,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Vemurafenib; Itraconazole; Medicine; Pharmacokinetics; Dosing; Pharmacology; Crossover study; Confidence interval; Area under the curve; Internal medicine; Adverse effect; Urology; Gastroenterology; Cancer; Dermatology; Pathology; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008611402,0.0002786057,0.0004925965,0.00007089526,0.00004037611,0.000005167812,0.0003098004,0.0001322292,0.00002590254],"category_scores_gemma":[0.0001549715,0.0001956392,0.00009695411,0.0002169915,0.0002751602,0.000006978342,0.000184267,0.0003592735,0.00001079717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000329015,"about_ca_system_score_gemma":0.0002203577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005391706,"about_ca_topic_score_gemma":0.000005666961,"domain_scores_codex":[0.9972196,0.0007135941,0.001010336,0.00047273,0.000261041,0.0003226777],"domain_scores_gemma":[0.9987492,0.0004842008,0.0003379342,0.0001528691,0.0001463516,0.0001294652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04003723,0.007356582,0.5949381,0.001108556,0.00198684,0.0004683764,0.01678299,0.02253914,0.2507949,0.00007469835,0.02202133,0.04189127],"study_design_scores_gemma":[0.0106411,0.003118777,0.09349313,0.00009746533,0.00006664481,0.000001728742,0.00008877293,0.000167542,0.8892707,0.000006454904,0.002752093,0.0002956446],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975774,0.00009887745,0.00002305323,0.0006951075,0.0002491959,0.001083023,0.00004758919,0.000007806079,0.0002180022],"genre_scores_gemma":[0.9967611,0.00006490888,0.0001687603,0.002624802,0.0001005637,0.0001117098,0.0001050797,0.00002426124,0.00003885577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6384757,"threshold_uncertainty_score":0.7977934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01222371963840386,"score_gpt":0.2778418450221536,"score_spread":0.2656181253837497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}