{"id":"W3038254578","doi":"10.1002/cpdd.822","title":"Effect of Itraconazole, a Potent CYP3A4 Inhibitor, on the Steady‐State Pharmacokinetics of Vemurafenib in Patients With <i>BRAF</i><sup>V600</sup> Mutation–Positive Malignancies","year":2020,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Vemurafenib; Itraconazole; Medicine; Pharmacokinetics; Dosing; Pharmacology; Crossover study; Confidence interval; Area under the curve; Internal medicine; Adverse effect; Urology; Gastroenterology; Cancer; Dermatology; Pathology; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000573252,0.0002694067,0.0006497716,0.0001345719,0.0001281807,0.0003238191,0.0001270545,0.0002396828,0.0008935453],"category_scores_gemma":[0.001323658,0.0002061332,0.0005806236,0.0002004168,0.0001976445,0.0003543058,0.0001487873,0.0007994598,0.0001310753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003669882,"about_ca_system_score_gemma":0.0003931908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000555387,"about_ca_topic_score_gemma":0.001198262,"domain_scores_codex":[0.9996628,0.0001422629,0.00002404908,0.00005873452,0.00004388469,0.00006830043],"domain_scores_gemma":[0.9993755,0.0002337098,0.0001484211,0.00004697666,0.00003246474,0.0001628621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3003532,0.01709053,0.09210833,0.0002558295,0.00200324,0.000886168,0.000458847,0.01056035,0.2882102,0.0002235751,0.001780956,0.2860688],"study_design_scores_gemma":[0.01203234,0.3327371,0.5794472,0.00002452756,0.001308536,0.001317876,0.0001295042,0.01351045,0.0560087,0.0001848085,0.003213498,0.0000854319],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992187,0.0002701492,0.0001062323,0.00003366413,0.000009181433,0.00001738605,0.00004206845,0.00001094415,0.0002916784],"genre_scores_gemma":[0.999413,0.00009329964,0.0001467149,0.0000255985,0.00001535742,0.00001810171,0.00008158744,0.000002592351,0.0002037778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008935453,"threshold_uncertainty_score":0.003031671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01222371963840386,"score_gpt":0.2778418450221536,"score_spread":0.2656181253837497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}