{"id":"W3038275062","doi":"10.1186/s40478-020-00961-2","title":"Quantitative patterns of motor cortex proteinopathy across ALS genotypes","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Oxford Biomedical Research Centre; Medical Research Council; Sheffield Teaching Hospitals NHS Foundation Trust; Brain Tumour Research; Motor Neurone Disease Association; National Institute for Health and Care Research; Alzheimer Society","keywords":"Neuroscience; Motor cortex; Biology; Neurology; Genotype; Cortex (anatomy); Psychology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001041696,0.00047863,0.000519073,0.001425686,0.0001790174,0.0005699123,0.0002392428,0.0003747397,0.001051233],"category_scores_gemma":[0.001916869,0.0002734806,0.0003937075,0.0005947403,0.0005466658,0.0002073474,0.0006607012,0.0003203884,0.0001954385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002761521,"about_ca_system_score_gemma":0.000147217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001915382,"about_ca_topic_score_gemma":0.002767521,"domain_scores_codex":[0.9991286,0.0002167637,0.00007934146,0.000313646,0.00019221,0.00006940583],"domain_scores_gemma":[0.9983674,0.0004939729,0.0005926318,0.0002848331,0.0001514997,0.0001097808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003027005,0.0001230584,0.6911558,0.0001244245,0.001137903,0.001171094,0.0007434036,0.004130832,0.2801963,0.0003022103,0.0002514151,0.0176366],"study_design_scores_gemma":[0.0000107108,0.0001282726,0.9924109,0.00000429863,0.00007756733,0.0006188531,0.00007150398,0.001905652,0.004417192,0.0002323845,0.0001095941,0.00001319616],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979876,0.0000944081,0.001308231,0.00001067326,0.000001092011,0.000007964282,0.0003525584,0.0000433531,0.0001940619],"genre_scores_gemma":[0.9990444,0.00002391029,0.0004681225,0.000005771867,7.3401e-7,0.000009699274,0.0002605729,0.00001856302,0.0001681902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001915382,"threshold_uncertainty_score":0.005509079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1455075833059916,"score_gpt":0.3791995615878819,"score_spread":0.2336919782818903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}