{"id":"W3038277510","doi":"10.1016/j.jcmgh.2020.06.007","title":"T-Cell Specificity Matters in IBD: Impaired IL10 Production Revealed by OmpC-Tetramers","year":2020,"lang":"en","type":"letter","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Crohn's and Colitis Foundation; BC Children's Hospital; Children's Hospital Foundation","keywords":"Immunology; Antigen; Immune system; Acquired immune system; Inflammatory bowel disease; Crohn's disease; Disease; Flagellin; Microbiome; Immunity; Inflammation; Mucosal immunology; Innate immune system; T cell; Biology; Medicine; Bioinformatics; Genetics; Internal medicine; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001718093,0.000636673,0.0007113682,0.0001848258,0.0001078872,0.0000316411,0.0002758795,0.001112282,0.00002613391],"category_scores_gemma":[0.00004123479,0.0007201358,0.0001870281,0.00006754004,0.0006592573,0.000008694789,0.0002583571,0.001191409,0.00001318946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000333376,"about_ca_system_score_gemma":0.00007459507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002072126,"about_ca_topic_score_gemma":0.00003729399,"domain_scores_codex":[0.996289,0.0007016052,0.0005544052,0.001452609,0.0001562916,0.0008460662],"domain_scores_gemma":[0.9989275,0.00001245236,0.0002586585,0.0005312175,0.00005521585,0.000214906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009417126,0.00008534358,0.07220401,0.0004045791,0.0001525854,0.005753066,0.00005813836,0.000003067571,0.2148847,0.000003858327,0.705471,0.00003791328],"study_design_scores_gemma":[0.008843574,0.002738625,0.01041666,0.0001399809,0.0008610187,0.001706123,0.0001722587,0.000287518,0.05313829,0.0002794945,0.9189391,0.002477416],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.840238,0.001659218,0.0006815686,0.1562033,0.0004274435,0.0006014031,0.00009979419,0.0000299057,0.00005941255],"genre_scores_gemma":[0.5288199,0.000823523,0.0002334823,0.4666873,0.0005162191,0.00009597879,0.00241281,0.000116833,0.0002940371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3114181,"threshold_uncertainty_score":0.999525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004818746047192755,"score_gpt":0.1879660154007287,"score_spread":0.1831472693535359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}