{"id":"W3038278491","doi":"10.1016/j.celrep.2020.107830","title":"Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Princess Margaret Cancer Foundation; Canadian Cancer Society Research Institute; Government of Ontario; Cancer Research Society","keywords":"Apoptosis; Programmed cell death; Senescence; Necrosis; Cell biology; DNA damage; Kinetics; Biology; In vivo; Cancer research; Cell; In vitro; DNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006627278,0.0001725252,0.0001592737,0.00001306415,0.00006983175,0.00005618473,0.0001116781,0.0001273151,0.00001468358],"category_scores_gemma":[0.0002611582,0.0001902226,0.00007590905,0.00007695598,0.00005374927,0.00000285357,0.0002918235,0.00008178696,0.000003466891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001586371,"about_ca_system_score_gemma":0.0000774234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000430234,"about_ca_topic_score_gemma":0.000008133284,"domain_scores_codex":[0.9988124,0.00001468394,0.0003071506,0.0004947839,0.0001382374,0.0002327254],"domain_scores_gemma":[0.9989746,0.00001822533,0.0002055804,0.0004940215,0.00006193457,0.0002456544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000157354,0.00004626589,0.007968914,0.00007655833,0.000009303981,0.00007573913,0.00006281564,0.0001574365,0.9807474,0.000004961668,0.009925375,0.0009095176],"study_design_scores_gemma":[0.0003605209,0.0001761306,0.001207105,0.00001137295,0.00004611236,0.0000474707,0.00005599181,0.0001482725,0.9266195,0.00007116408,0.07096498,0.000291362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898873,0.001914645,0.0008355281,0.0003358133,0.0002164086,0.0001655867,0.00002605405,0.00001780047,0.006600867],"genre_scores_gemma":[0.9963537,0.0008974775,0.0009524071,0.001045206,0.0003394842,0.000008354197,0.00007834813,0.00003604201,0.0002890055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0610396,"threshold_uncertainty_score":0.7757052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007619219961827284,"score_gpt":0.1997936310959835,"score_spread":0.1921744111341562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}