{"id":"W3038278491","doi":"10.1016/j.celrep.2020.107830","title":"Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Princess Margaret Cancer Foundation; Canadian Cancer Society Research Institute; Government of Ontario; Cancer Research Society","keywords":"Apoptosis; Programmed cell death; Senescence; Necrosis; Cell biology; DNA damage; Kinetics; Biology; In vivo; Cancer research; Cell; In vitro; DNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007689316,0.0002915029,0.0004159299,0.0003294673,0.0001369094,0.0005843298,0.0002109122,0.0003696437,0.001056488],"category_scores_gemma":[0.001842788,0.0002331752,0.0002378767,0.0001780345,0.0003697859,0.0007760134,0.0002530791,0.0005735062,0.0004075265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003940362,"about_ca_system_score_gemma":0.0003562085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003936979,"about_ca_topic_score_gemma":0.000385885,"domain_scores_codex":[0.9994738,0.00009898767,0.00004620128,0.0001453114,0.0001627304,0.00007294099],"domain_scores_gemma":[0.998823,0.000540383,0.0002812591,0.00009245444,0.0001713884,0.00009152349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002505579,0.00001422423,0.001545424,0.00006987953,0.000007938806,0.00004952365,0.00007708462,0.0003360611,0.9926885,0.0001648586,0.00003587429,0.004760098],"study_design_scores_gemma":[0.00001255113,0.0003086488,0.005177177,0.000010677,0.00001436567,0.0002496341,0.00004087366,0.004092765,0.9882703,0.0002328686,0.001576354,0.00001380261],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9209316,0.007200839,0.06799857,0.0001999709,0.00006480093,0.0001574105,0.0006588022,0.0002432387,0.002544801],"genre_scores_gemma":[0.9837145,0.001473746,0.01207417,0.0000693515,0.00001349292,0.00008322045,0.0003206129,0.00006875769,0.00218211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056488,"threshold_uncertainty_score":0.004066527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007619219961827284,"score_gpt":0.1997936310959835,"score_spread":0.1921744111341562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}