{"id":"W3038278697","doi":"10.1038/s41375-020-0958-y","title":"Targeting nuclear import and export in hematological malignancies","year":2020,"lang":"en","type":"review","venue":"Leukemia","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Karyopherin; Importin; Nuclear transport; Biology; Carcinogenesis; Cancer research; Nuclear localization sequence; Cancer; Cell nucleus; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003523556,0.0006291302,0.0008839706,0.001455184,0.0001931573,0.000611981,0.0006409981,0.0007982696,0.00292599],"category_scores_gemma":[0.0003248107,0.0002052796,0.0003249497,0.001174309,0.0003162909,0.0008254605,0.0005631091,0.001524243,0.001786951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005386911,"about_ca_system_score_gemma":0.0005710187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006442288,"about_ca_topic_score_gemma":0.001338019,"domain_scores_codex":[0.9999084,0.00001447103,0.00001209046,0.00001589386,0.00003665486,0.00001246879],"domain_scores_gemma":[0.9999017,0.00003961192,0.00001536002,0.000003352834,0.00002605465,0.00001389409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009935398,0.00006827835,0.0001050597,0.01322507,0.00007139648,0.0002607379,0.00004955125,0.0004253883,0.003927558,0.003537457,0.03184333,0.9463867],"study_design_scores_gemma":[0.00001971902,0.0000932011,0.0004585913,0.001499429,0.00006274381,0.001242976,0.00002334131,0.00006756317,0.0005819763,0.00119619,0.9947441,0.00001024167],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001359629,0.9985561,0.0001112528,0.0001795948,0.0001517365,0.000004008957,0.00001371974,0.000008704465,0.0008388359],"genre_scores_gemma":[0.0005927768,0.9983355,0.0001412542,0.0001700924,0.0001040342,0.000005251015,0.00002924148,0.00000154682,0.0006202862],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00292599,"threshold_uncertainty_score":0.009788394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561377391950826,"score_gpt":0.2565196548240379,"score_spread":0.2409058809045296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}