{"id":"W3038487399","doi":"10.1158/1078-0432.ccr-20-0219","title":"A Biomarker-enriched, Randomized Phase II Trial of Adavosertib (AZD1775) Plus Paclitaxel and Carboplatin for Women with Platinum-sensitive <i>TP53</i> -mutant Ovarian Cancer","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Centre Hospitalier de l’Université de Montréal; Princess Margaret Cancer Centre","funders":"Merck; AstraZeneca","keywords":"Carboplatin; Medicine; Tolerability; Internal medicine; Chemotherapy; Oncology; Adverse effect; Ovarian cancer; Response Evaluation Criteria in Solid Tumors; Gastroenterology; Placebo; Clinical endpoint; Hazard ratio; Pemetrexed; Cancer; Progression-free survival; Randomized controlled trial; Surgery; Phases of clinical research; Confidence interval; Cisplatin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003771257,0.0003488995,0.002207257,0.0001346553,0.0002360856,0.000043783,0.000161672,0.0002565789,0.0003098848],"category_scores_gemma":[0.002447258,0.0002374174,0.000304521,0.0006738101,0.001033771,0.00008975728,0.0001832738,0.0006684265,0.000002922988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005196455,"about_ca_system_score_gemma":0.002545467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001624363,"about_ca_topic_score_gemma":0.00031463,"domain_scores_codex":[0.995133,0.0007627894,0.001323507,0.001005556,0.0009605706,0.000814587],"domain_scores_gemma":[0.9927922,0.004625434,0.0003819276,0.0004435196,0.0008335452,0.000923307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9422181,0.001605959,0.000692351,0.0004016701,0.001965304,0.0001162482,0.002608816,0.000007668042,0.001574104,0.0002321305,0.00180158,0.04677611],"study_design_scores_gemma":[0.9621296,0.02505722,0.0009099675,0.0004531891,0.0006254366,0.000005720431,0.0008411531,0.002485547,0.001797382,0.0002620477,0.005140094,0.0002926277],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643668,0.001780184,0.0002054393,0.0237735,0.0002826398,0.007965884,0.0006277967,0.00004384965,0.0009538906],"genre_scores_gemma":[0.9893754,0.002504131,0.0006004649,0.00109165,0.0009954246,0.005062074,0.00003267945,0.00007124059,0.0002668982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04648348,"threshold_uncertainty_score":0.9681599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2055678216368092,"score_gpt":0.4904681500289786,"score_spread":0.2849003283921694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}