{"id":"W3038503895","doi":"10.1016/j.celrep.2020.107781","title":"The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Canada Research Chairs; Government of Canada","keywords":"Leucine-rich repeat; MAPK/ERK pathway; Cell biology; Mutant; Signal transduction; HEK 293 cells; Wild type; Phosphorylation; Immunoprecipitation; Chemistry; Molecular biology; Biology; Kinase; Receptor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001161763,0.0003528449,0.0002423315,0.0002699497,0.0002784028,0.0003837466,0.0002649861,0.0003325913,0.002097012],"category_scores_gemma":[0.0001180425,0.0001734816,0.000273658,0.0001482057,0.0003067542,0.0002378053,0.0002024346,0.000657617,0.001086607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005034803,"about_ca_system_score_gemma":0.0002775092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005584195,"about_ca_topic_score_gemma":0.001018915,"domain_scores_codex":[0.9998234,0.00001934298,0.00001212921,0.00004456305,0.0000429227,0.00005772169],"domain_scores_gemma":[0.9998845,0.0000162891,0.00003675662,0.000009342562,0.00001372368,0.00003941837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001635189,0.00002633987,0.0002538622,0.00003611278,0.000003336793,0.00005695263,0.00001611045,0.00007064272,0.9976568,0.0001496101,0.0001043338,0.001462389],"study_design_scores_gemma":[0.0000243612,0.0001351499,0.005874916,0.000007734019,0.00001587699,0.0002931721,0.00005038528,0.001955232,0.9865242,0.00007041512,0.005039165,0.00000935291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905903,0.002196439,0.003367658,0.0002050608,0.00004325464,0.00002265766,0.0007335994,0.0002734327,0.002567526],"genre_scores_gemma":[0.9941758,0.0004149701,0.001324603,0.00006309067,0.000006230693,0.00002479958,0.0007785835,0.00003965373,0.003172141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002097012,"threshold_uncertainty_score":0.007015228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092497338942131,"score_gpt":0.2095081150056689,"score_spread":0.1985831416162476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}