{"id":"W3038503895","doi":"10.1016/j.celrep.2020.107781","title":"The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Canada Research Chairs; Government of Canada","keywords":"Leucine-rich repeat; MAPK/ERK pathway; Cell biology; Mutant; Signal transduction; HEK 293 cells; Wild type; Phosphorylation; Immunoprecipitation; Chemistry; Molecular biology; Biology; Kinase; Receptor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001250486,0.0001039993,0.0001085754,0.00001418232,0.0001364101,0.00001795415,0.00006292374,0.0001016026,0.000005033231],"category_scores_gemma":[0.0003126182,0.00007507747,0.00003729162,0.0001146915,0.0000705171,0.000005918244,0.00007043321,0.00003703441,5.464156e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005757215,"about_ca_system_score_gemma":0.0000606499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001294047,"about_ca_topic_score_gemma":0.000004124183,"domain_scores_codex":[0.9991438,0.00003923199,0.0002886184,0.0002951547,0.0001171818,0.0001159995],"domain_scores_gemma":[0.9991603,0.00002034654,0.0002900999,0.0003119321,0.000146948,0.00007041057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004723013,0.00001394484,0.002978184,0.00002336812,0.00001056626,0.00001872929,0.0001166052,0.0000175337,0.9843439,0.000004419131,0.01201552,0.0004099549],"study_design_scores_gemma":[0.0001566596,0.00010908,0.001887992,0.00001418469,0.000009696381,0.00002937498,0.0002279391,0.00002775043,0.9450751,0.00004533563,0.05232739,0.00008952057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971507,0.0008431334,0.0003424401,0.0005666755,0.00005882491,0.0002303631,0.000002430982,0.00001363344,0.0007917583],"genre_scores_gemma":[0.9977693,0.0003078539,0.0001433276,0.0001342439,0.00011371,0.00001555777,0.0001224667,0.00001554078,0.001378004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04031188,"threshold_uncertainty_score":0.3061571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092497338942131,"score_gpt":0.2095081150056689,"score_spread":0.1985831416162476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}