{"id":"W3038511595","doi":"10.1016/j.expneurol.2020.113396","title":"Compromised IGF signaling causes caspase-6 activation in Huntington disease","year":2020,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Arbejdstilsynet; Københavns Universitet; Canadian Institutes of Health Research; European Commission; Michael Smith Health Research BC","keywords":"Huntingtin; Huntington's disease; Huntingtin Protein; Biology; Mutant; Signal transduction; Genetically modified mouse; Apoptosis; Transgene; Neurodegeneration; Caspase; Cell biology; Growth factor; Programmed cell death; Cancer research; Endocrinology; Internal medicine; Gene; Genetics; Disease; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002875494,0.0002183732,0.0001989578,0.00008114259,0.0001107461,0.00003910051,0.0002416078,0.00004176749,0.0002322025],"category_scores_gemma":[0.0004381392,0.0002109315,0.00006286441,0.0002534163,0.0001492271,0.0001426856,0.0001503198,0.000196041,0.00008332868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001952982,"about_ca_system_score_gemma":0.00005512686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001723971,"about_ca_topic_score_gemma":0.000001638159,"domain_scores_codex":[0.9980056,0.0004020396,0.0002649202,0.0007619773,0.0002222986,0.0003432053],"domain_scores_gemma":[0.9992377,0.000193051,0.000094132,0.000189819,0.00001332885,0.0002719567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004672707,0.0002283158,0.003674873,0.000008152543,0.000001230234,0.00007151555,0.0003919258,0.001366614,0.9934421,0.0002025844,0.0001131848,0.00003225608],"study_design_scores_gemma":[0.0009831027,0.0002893096,0.006873925,0.000003729243,0.000002594552,0.000001607012,0.00004809804,0.001666894,0.9896635,0.00003710177,0.000246139,0.0001840147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958533,0.00002599031,0.0000456633,0.003186865,0.0001780379,0.0004224018,0.00001169624,0.0001133776,0.0001626867],"genre_scores_gemma":[0.9800703,0.000002379035,0.00003422581,0.0196328,0.000122711,0.00007853568,0.000007908649,0.00003756906,0.0000135791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01644593,"threshold_uncertainty_score":0.8601537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04901001401314906,"score_gpt":0.2904970934077209,"score_spread":0.2414870793945718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}