{"id":"W3038603887","doi":"10.1126/sciadv.aaz9072","title":"Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA <i>NEAT1</i>","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"National Institute of General Medical Sciences; National Cancer Institute; Fondation contre le Cancer; Novo Nordisk Fonden","keywords":"Gene isoform; Biogenesis; Polyadenylation; RNA; Cell biology; Integrator; Biology; Chemistry; Computational biology; Computer science; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783068,0.0002131107,0.0001494238,0.0002143694,0.0002183278,0.0004911609,0.0002199989,0.0001724078,0.001999085],"category_scores_gemma":[0.0002968753,0.0001386898,0.0002145665,0.0001078597,0.0002502681,0.0004006538,0.0003501633,0.0004202774,0.0004417858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000401109,"about_ca_system_score_gemma":0.0003336542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009957113,"about_ca_topic_score_gemma":0.002613438,"domain_scores_codex":[0.9998798,0.000008008734,0.00001170599,0.00003999185,0.00003739129,0.00002301035],"domain_scores_gemma":[0.999809,0.00002089427,0.00006553299,0.00002152786,0.00002266244,0.00006045778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008018168,0.00001026402,0.002004855,0.00003334443,0.000005487094,0.00005543301,0.00002109678,0.00004013122,0.9949202,0.000264032,0.0001189342,0.002446116],"study_design_scores_gemma":[0.00001997221,0.0001562299,0.05020218,0.00001390279,0.00002421813,0.0004951726,0.00008099081,0.002180336,0.9401671,0.0002815742,0.006358149,0.00002021793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905676,0.001439474,0.004691775,0.0001227275,0.0000680123,0.00001574378,0.0003605216,0.0002694247,0.002464843],"genre_scores_gemma":[0.9949046,0.0003491198,0.00180889,0.00006330973,0.00001103986,0.000007646664,0.0004028883,0.00005129189,0.002401243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001999085,"threshold_uncertainty_score":0.006687582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021142916057454,"score_gpt":0.2838146253243197,"score_spread":0.2736031961637452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}