{"id":"W3038834451","doi":"10.1002/chir.23258","title":"Chiral bioanalytical methods in bioequivalence studies of intravenous vs. oral formulations of ibuprofen","year":2020,"lang":"en","type":"article","venue":"Chirality","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"World Health Organization","keywords":"Bioequivalence; Ibuprofen; Enantiomer; Bioanalysis; Chemistry; Chromatography; Pharmacology; Analyte; Pharmacokinetics; Stereochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007710424,0.0001277481,0.0006888203,0.00008163239,0.00002404356,0.000001949161,0.00009368936,0.00008217449,0.00003642799],"category_scores_gemma":[0.001177516,0.00009991951,0.0001268282,0.0003853145,0.0002850287,0.00006011217,0.00007824908,0.0001896131,0.000004033632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003934737,"about_ca_system_score_gemma":0.00009330732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004142248,"about_ca_topic_score_gemma":0.00001091662,"domain_scores_codex":[0.998681,0.0001678185,0.0005586216,0.0001959985,0.0001936932,0.0002028782],"domain_scores_gemma":[0.9992248,0.0001753512,0.0001439804,0.0002219123,0.0001109008,0.0001230478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001813863,0.000860504,0.8480065,0.006976982,0.0006207691,0.00008533904,0.01507052,0.0000404105,0.07445091,0.02617617,0.0004402887,0.02545768],"study_design_scores_gemma":[0.002658457,0.001692314,0.8261955,0.0003211499,0.0003256625,0.000007425762,0.0005716434,0.003243276,0.160834,0.00367822,0.0002235276,0.0002489019],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964104,0.0003183395,0.001036825,0.001207103,0.0001064907,0.0003654775,0.00001703204,0.00002422454,0.0005140891],"genre_scores_gemma":[0.9871226,0.00003920321,0.01245715,0.0002511805,0.00008609126,0.000007922681,0.000007685539,0.000009343096,0.00001881876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08638304,"threshold_uncertainty_score":0.4074599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1461672434086554,"score_gpt":0.4548480007074303,"score_spread":0.3086807572987749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}