{"id":"W3038973605","doi":"10.1016/j.jacbts.2020.05.004","title":"Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis","year":2020,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of Ottawa; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Horizon 2020; European Research Council; Fonds de Recherche du Québec - Santé; National Institutes of Health; Akebia Therapeutics; Conseil Régional des Pays de la Loire; Skånes universitetssjukhus; Agence Nationale de la Recherche; Fondazione Gigi e Pupa Ferrari; Medical Research Council; Medical Research Council Canada; Servier; Knut och Alice Wallenbergs Stiftelse; Pfizer; Fritz Thyssen Stiftung; Deutsche Forschungsgemeinschaft; Fédération Française de Cardiologie; Canadian Institutes of Health Research; Daimler und Benz Stiftung; Stiftelsen för Strategisk Forskning; National Heart, Lung, and Blood Institute; Crafoordska Stiftelsen; Cancer Research UK; Hjärt-Lungfonden; Ionis Pharmaceuticals; Merck; Edwards Lifesciences; Boehringer Ingelheim; Medtronic; Assistance Publique - Hôpitaux de Paris; Stiftelsen för Strategisk Forskning; National Institute for Health and Care Research; Novartis; Vetenskapsrådet; Ministero della Salute","keywords":"PCSK9; Odds ratio; Stenosis; Internal medicine; Cardiology; Medicine; Confidence interval; Aortic valve; Aortic valve stenosis; In vitro; Chemistry; Cholesterol; Lipoprotein; LDL receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002606936,0.0007104127,0.00201683,0.0004913911,0.0002013629,0.001142572,0.0004008856,0.0009248749,0.001379621],"category_scores_gemma":[0.004580362,0.0004242081,0.004531896,0.0008649316,0.0002972324,0.0002331394,0.0003223237,0.0009359412,0.0001910781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005540287,"about_ca_system_score_gemma":0.0003920349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009957161,"about_ca_topic_score_gemma":0.001452685,"domain_scores_codex":[0.9988139,0.0005866159,0.0001756601,0.0001821462,0.0001582721,0.00008353905],"domain_scores_gemma":[0.9975626,0.001552548,0.0005033293,0.0001538104,0.0001422876,0.00008526454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2392829,0.002505116,0.1341062,0.03242522,0.3683687,0.001020513,0.0002360292,0.006477177,0.05871385,0.001576381,0.003799815,0.1514881],"study_design_scores_gemma":[0.03433507,0.05791047,0.1815913,0.002412129,0.6246614,0.001547872,0.0002550907,0.006603822,0.06267893,0.002621462,0.02522253,0.0001599236],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6928294,0.3006384,0.001711182,0.001025655,0.0008457833,0.0001328046,0.0008704446,0.00004295566,0.001903229],"genre_scores_gemma":[0.9691278,0.02844774,0.0006347526,0.0004308546,0.000235146,0.00005999824,0.0003110411,0.000007943576,0.0007448577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002606936,"threshold_uncertainty_score":0.01378691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02108164748262714,"score_gpt":0.2631322407117119,"score_spread":0.2420505932290848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}