{"id":"W3039146726","doi":"10.1073/pnas.2000312117","title":"An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; Pancreatic Cancer Action Network; Canadian Institutes of Health Research; Feinberg School of Medicine; National Cancer Institute; Lynn Sage Cancer Research Foundation; Government of Canada; Hospital for Sick Children; Avon Foundation for Women; Chicago Community Trust; Chicago Biomedical Consortium; Robert H. Lurie Comprehensive Cancer Center","keywords":"Mutant; KRAS; In vivo; Wild type; Cancer research; Gene isoform; In vitro; Biology; Mutation; Chemistry; Cell biology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001503416,0.0002811069,0.0001745698,0.0001645748,0.00009122428,0.0001776662,0.0002234984,0.0004040576,0.001050958],"category_scores_gemma":[0.00009466687,0.0001048159,0.0002076873,0.0001209852,0.000260486,0.0001474027,0.0001574361,0.0006706406,0.0002524776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003263692,"about_ca_system_score_gemma":0.0003610422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000632923,"about_ca_topic_score_gemma":0.0008177652,"domain_scores_codex":[0.9999003,0.00001167248,0.000006907263,0.00002010007,0.00003056324,0.00003044008],"domain_scores_gemma":[0.9999236,0.00001758261,0.00002111643,0.000008070653,0.000007488262,0.00002215145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004305813,0.00002515456,0.00005398377,0.0000119869,0.000003179603,0.00002959975,0.000005330335,0.00006719652,0.9988716,0.0001974942,0.00002906446,0.0006622363],"study_design_scores_gemma":[0.00002568676,0.0005403538,0.0006697183,0.000003716352,0.00001467638,0.0003773807,0.000006669699,0.0009089933,0.9955606,0.00003812639,0.001851502,0.000002480864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890827,0.001073095,0.007511115,0.0001551246,0.00003851537,0.00003745561,0.0001775274,0.0001099623,0.001814435],"genre_scores_gemma":[0.9913803,0.0004735906,0.005238799,0.00004483765,0.000007535691,0.00002193564,0.0002824494,0.00001339805,0.00253716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001050958,"threshold_uncertainty_score":0.00351578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06288291721560926,"score_gpt":0.3264472687250354,"score_spread":0.2635643515094261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}