{"id":"W3039220488","doi":"10.1038/s42003-020-1072-4","title":"Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Blood Cancer UK; University of British Columbia; Universität Wien; Medical Research Council; Österreichischen Akademie der Wissenschaften; Medizinische Universität Wien; Branco Weiss Fellowship – Society in Science; Faculty of Medicine, University of British Columbia; Yale University","keywords":"Cytosol; Effector; Secretion; Intracellular; Type three secretion system; Cell biology; Salmonella; Biology; Macromolecule; Small molecule; Recombinant DNA; Computational biology; Bacteria; Biochemistry; Genetics; Enzyme; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008746058,0.00005838075,0.00007709387,0.00001879247,0.0002552307,0.000007524698,0.00049673,0.00003729274,0.0003367123],"category_scores_gemma":[0.0000538362,0.0000433585,0.00005827127,0.0001617853,0.0001645843,0.00002293592,0.000332203,0.00008433023,0.0002245395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004629375,"about_ca_system_score_gemma":0.00001587372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008775409,"about_ca_topic_score_gemma":0.0001320837,"domain_scores_codex":[0.9995539,0.00003376694,0.000158269,0.0001183883,0.00002729569,0.0001083328],"domain_scores_gemma":[0.9992532,0.0001704903,0.00006846974,0.0004454443,0.00001901573,0.00004336814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004994845,0.00008117093,0.0003411653,0.000003544665,0.00001107551,2.745111e-8,0.000251631,0.00391848,0.9896196,0.0004634968,0.00181074,0.00344912],"study_design_scores_gemma":[0.0009789325,0.0008355118,0.02303959,0.00003351947,0.00006544696,0.000005819234,0.0006183557,0.07345933,0.09783638,0.0001053363,0.8026431,0.0003787152],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9184168,0.00006723079,0.05340997,0.02477322,0.0001412137,0.001194707,0.0002505159,0.00003926967,0.001707072],"genre_scores_gemma":[0.992045,0.000007207685,0.006583504,0.001062087,0.00002015324,0.0001459157,0.00008770022,0.000005761519,0.0000426119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8917832,"threshold_uncertainty_score":0.3686763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06717155399686033,"score_gpt":0.2804345153528436,"score_spread":0.2132629613559833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}