{"id":"W3039220488","doi":"10.1038/s42003-020-1072-4","title":"Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Blood Cancer UK; University of British Columbia; Universität Wien; Medical Research Council; Österreichischen Akademie der Wissenschaften; Medizinische Universität Wien; Branco Weiss Fellowship – Society in Science; Faculty of Medicine, University of British Columbia; Yale University","keywords":"Cytosol; Effector; Secretion; Intracellular; Type three secretion system; Cell biology; Salmonella; Biology; Macromolecule; Small molecule; Recombinant DNA; Computational biology; Bacteria; Biochemistry; Genetics; Enzyme; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137763,0.0002961008,0.0001669704,0.0001421758,0.0001173242,0.0001951521,0.0001595741,0.0003066623,0.0009055475],"category_scores_gemma":[0.00005533954,0.000127056,0.0001826922,0.00009666472,0.0001485283,0.0001262714,0.0002451013,0.000434686,0.0006605907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002014216,"about_ca_system_score_gemma":0.000240655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003104974,"about_ca_topic_score_gemma":0.0004963658,"domain_scores_codex":[0.9999378,0.00001046281,0.000005175069,0.00001441247,0.00001924872,0.00001304604],"domain_scores_gemma":[0.999947,0.000006519221,0.00001530771,0.000007510379,0.000008395085,0.0000153871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001192421,0.000006565891,0.0000242742,0.00001949555,0.000001326647,0.00001270823,0.000003451456,0.00003554294,0.9992023,0.00013388,0.00002509014,0.0005235765],"study_design_scores_gemma":[0.00000637775,0.0001750472,0.0003844108,0.000003825276,0.000007318684,0.0001592941,0.0000081331,0.001059735,0.9949896,0.00003076348,0.003171638,0.000003769884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9247078,0.001599179,0.06919741,0.0002424751,0.00007259221,0.00009376542,0.0005603099,0.000661677,0.002864749],"genre_scores_gemma":[0.9657796,0.0008580973,0.02846311,0.00007055504,0.000007315028,0.00004593846,0.0008043454,0.00004759882,0.003923345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009055475,"threshold_uncertainty_score":0.003029346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06717155399686033,"score_gpt":0.2804345153528436,"score_spread":0.2132629613559833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}