{"id":"W3039285421","doi":"10.1002/prca.202000012","title":"Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post‐DRE Urines for Quantitation and Genotype Determination","year":2020,"lang":"en","type":"article","venue":"PROTEOMICS - CLINICAL APPLICATIONS","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute","keywords":"Concordance; Prostate cancer; Urine; Genotype; Biomarker; Single-nucleotide polymorphism; SNP; Mass spectrometry; Medicine; Prostate-specific antigen; Internal medicine; Oncology; Cancer; Chromatography; Biology; Chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00116612,0.0008506374,0.000442517,0.001277044,0.0005067359,0.0005383062,0.0004332309,0.000860177,0.001240904],"category_scores_gemma":[0.002162143,0.0002368224,0.0004082019,0.0007709725,0.0005075447,0.0001789722,0.0003079635,0.0004737698,0.0005679812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00026917,"about_ca_system_score_gemma":0.0004733306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005294782,"about_ca_topic_score_gemma":0.001040845,"domain_scores_codex":[0.9989154,0.000222469,0.00005697132,0.0002764667,0.0004580987,0.0000706019],"domain_scores_gemma":[0.9991764,0.0001996041,0.0002617177,0.0001115493,0.0001757352,0.00007495141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001088683,0.0001914058,0.01499728,0.0001761252,0.00009843877,0.0002725561,0.0001118096,0.0003402435,0.9637438,0.0002048637,0.0003938499,0.01838092],"study_design_scores_gemma":[0.00009294243,0.001580096,0.08789314,0.00005715029,0.0001338728,0.002945922,0.0001310008,0.006929799,0.8966345,0.0005523764,0.003002701,0.00004652707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9477771,0.00277459,0.04466045,0.0002494903,0.0002736592,0.0002747475,0.001643738,0.0006259194,0.001720392],"genre_scores_gemma":[0.9539639,0.0008024539,0.04161343,0.0005187365,0.00006707506,0.0002596592,0.0009697122,0.00009694338,0.001708016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001277044,"threshold_uncertainty_score":0.006167114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05027592224781995,"score_gpt":0.3646455630044156,"score_spread":0.3143696407565957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}