{"id":"W3039294617","doi":"10.1136/heartjnl-2020-316722","title":"Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans","year":2020,"lang":"en","type":"article","venue":"Heart","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of Ottawa; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Medical Research Council; Canadian Institutes of Health Research; Stiftelsen för Strategisk Forskning; Hjärt-Lungfonden; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; Vetenskapsrådet; Fondation pour la Recherche Médicale; National Institute for Health and Care Research; Assistance Publique - Hôpitaux de Paris; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Agence Nationale de la Recherche; Stiftelsen för Strategisk Forskning","keywords":"Medicine; Lipoprotein-associated phospholipase A2; Internal medicine; Lipoprotein(a); Epidemiology; Single-nucleotide polymorphism; Cardiology; Aortic valve stenosis; Stenosis; Genetic epidemiology; Aortic valve; Lipoprotein; Gastroenterology; Endocrinology; Genotype; Surgery; Cholesterol; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000502355,0.0001378577,0.0003240987,0.00003928286,0.00004966171,0.00002243313,0.00002291812,0.00007035916,0.00007806481],"category_scores_gemma":[0.0000638105,0.0001313911,0.0003530358,0.0001836824,0.000035526,0.00003273974,0.00004594308,0.000128094,0.0000557497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007457821,"about_ca_system_score_gemma":0.00005723583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004591162,"about_ca_topic_score_gemma":0.00001746246,"domain_scores_codex":[0.9990914,0.00004060618,0.0001437712,0.0002821837,0.0002026753,0.0002393728],"domain_scores_gemma":[0.999438,0.00002736101,0.00003201671,0.00016585,0.00003580206,0.000300925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001268527,0.0004137365,0.9936243,0.00006290652,0.0002652695,0.00004180779,0.0003434609,0.000003120316,0.001483551,0.00000445303,0.0006598349,0.00297066],"study_design_scores_gemma":[0.00205993,0.0003180702,0.995109,0.00005637174,0.0003710093,0.000001791275,0.00006987756,0.0001675339,0.001320182,0.00001956853,0.0003929162,0.0001137372],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967122,0.001143581,0.000002747296,0.001234738,0.00004770235,0.0004964614,0.00004341537,0.0000459552,0.0002731791],"genre_scores_gemma":[0.9986372,0.0001597894,0.00004101815,0.000939587,0.00006092895,0.00003974931,0.00002461125,0.0000256684,0.00007142264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002856923,"threshold_uncertainty_score":0.5357974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03079553441407334,"score_gpt":0.3309098279810915,"score_spread":0.3001142935670181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}