{"id":"W3039302117","doi":"10.1158/0008-5472.can-20-0106","title":"Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; ADA Foundation; National Cancer Institute; National Institutes of Health; Université de Montréal; Novartis; American Diabetes Association","keywords":"Cyclin D1; Medicine; Internal medicine; Endocrinology; Hyperinsulinemia; Metformin; Cancer; Diabetes mellitus; Type 2 diabetes; Cancer research; Cell cycle; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007233769,0.0002176061,0.0001683767,0.0003936069,0.0001306178,0.0003094052,0.00005651081,0.0001077392,0.001564833],"category_scores_gemma":[0.0001012535,0.0001277111,0.000173642,0.0002693766,0.0001300628,0.00009889607,0.0001420477,0.0003393946,0.0002210454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002000306,"about_ca_system_score_gemma":0.0001350189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007504348,"about_ca_topic_score_gemma":0.001021564,"domain_scores_codex":[0.9999392,0.000006796375,0.000005733906,0.00001717227,0.00001423771,0.00001693436],"domain_scores_gemma":[0.9999125,0.000008604059,0.00003773505,0.000007648398,0.00000796883,0.00002542272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006061547,0.00006089918,0.01052153,0.00005692388,0.00001906576,0.0003198646,0.00001744876,0.00005340618,0.9832518,0.00009837571,0.0001369296,0.004857596],"study_design_scores_gemma":[0.00006233875,0.0006251858,0.3127174,0.00001354968,0.00006992596,0.005460893,0.00009501336,0.000714524,0.6735877,0.0001843784,0.006451501,0.00001748294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994148,0.002371867,0.001037852,0.00007405529,0.00002177522,0.00001942361,0.0007013844,0.0000730996,0.001552545],"genre_scores_gemma":[0.9962907,0.001146374,0.0006639716,0.00006250761,0.000007151849,0.00001938396,0.0006089665,0.00001270607,0.001188273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001564833,"threshold_uncertainty_score":0.005234897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05712041998364088,"score_gpt":0.3447255597384407,"score_spread":0.2876051397547998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}