{"id":"W3039390201","doi":"10.1021/acs.jnatprod.0c00171","title":"Synthesis and Antimicrobial Activity of <i>Burkholderia</i> -Related 4-Hydroxy-3-methyl-2-alkenylquinolines (HMAQs) and Their <i>N</i> -Oxide Counterparts","year":2020,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Antimicrobial; Chemistry; Biological activity; Stereochemistry; Burkholderia; Organic chemistry; Bacteria; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307548,0.0003120257,0.0001355132,0.0001372665,0.00009862814,0.00009837012,0.0002114289,0.0002132185,0.0006181346],"category_scores_gemma":[0.0001271345,0.00008067162,0.0001822729,0.0001388403,0.0001041136,0.000241389,0.0002009551,0.0002097515,0.0002653105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001248601,"about_ca_system_score_gemma":0.0001751557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004761948,"about_ca_topic_score_gemma":0.0009238626,"domain_scores_codex":[0.9999244,0.00001296756,0.000009926835,0.00001321176,0.00001866689,0.00002082764],"domain_scores_gemma":[0.9999437,0.000004516489,0.00001878892,0.000004717283,0.00001331983,0.00001479924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001114546,0.00005250485,0.0002995229,0.0002717607,0.00001111531,0.0001443828,0.00004057113,0.0003839057,0.9904573,0.0003521153,0.00008523906,0.007790181],"study_design_scores_gemma":[0.0000240399,0.001454546,0.002185021,0.00002481794,0.00002440481,0.0003004911,0.00003784684,0.0006431531,0.9857337,0.00009045815,0.009463768,0.00001761775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808159,0.007193973,0.005980166,0.0001121775,0.00005026127,0.0001019241,0.0004678713,0.00006703276,0.005210611],"genre_scores_gemma":[0.9906663,0.002926938,0.004469862,0.00004559348,0.0000109763,0.00003336527,0.0003434214,0.000008805022,0.001494757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006181346,"threshold_uncertainty_score":0.002067864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434859682098715,"score_gpt":0.2305262315941342,"score_spread":0.216177634773147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}