{"id":"W3039390201","doi":"10.1021/acs.jnatprod.0c00171","title":"Synthesis and Antimicrobial Activity of <i>Burkholderia</i> -Related 4-Hydroxy-3-methyl-2-alkenylquinolines (HMAQs) and Their <i>N</i> -Oxide Counterparts","year":2020,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Antimicrobial; Chemistry; Biological activity; Stereochemistry; Burkholderia; Organic chemistry; Bacteria; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004012887,0.0002543869,0.0008054823,0.0001679158,0.00008197322,0.00003625312,0.00009277486,0.000140453,0.00001158407],"category_scores_gemma":[0.0009598075,0.0001741895,0.000143444,0.00041547,0.0002106317,0.0003761647,0.00007698291,0.0005669403,0.000001318665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002756359,"about_ca_system_score_gemma":0.0001298738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000221195,"about_ca_topic_score_gemma":0.000001388552,"domain_scores_codex":[0.9986021,0.00009082142,0.0005757223,0.0002911146,0.0002153899,0.0002248669],"domain_scores_gemma":[0.9984006,0.000143997,0.0005731868,0.0001834906,0.000500952,0.0001978083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006448866,0.0001499519,0.0009281152,0.0003905266,0.0002573172,0.00003237912,0.0003873452,0.000006365381,0.9862204,0.000006769128,0.003311286,0.007664695],"study_design_scores_gemma":[0.001537956,0.0005043846,0.006365141,0.000425511,0.0003228197,0.00162923,0.00006197064,0.000147157,0.984969,0.0000154545,0.003845023,0.000176377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813792,0.003845487,0.00001443148,0.01378325,0.0005998077,0.0002751854,0.00001602958,0.0000249673,0.00006168552],"genre_scores_gemma":[0.996947,0.001264554,0.0005594997,0.0006388251,0.0005175864,0.000001644711,0.000001608061,0.00002793323,0.00004133044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01556786,"threshold_uncertainty_score":0.710324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434859682098715,"score_gpt":0.2305262315941342,"score_spread":0.216177634773147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}