{"id":"W3039508753","doi":"10.1101/2020.07.03.185967","title":"Viability and mitochondrial bioenergetic functions in human colon cancer cells are not affected by treatment with peptides mtCPP1, UPF25, mtgCPP, and mtCPP1gHO","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"European Regional Development Fund; Vetenskapsrådet; Swedish Cancer Foundation","keywords":"Bioenergetics; Viability assay; Mitochondrion; Respirometry; Cancer cell; Mitochondrial respiratory chain; Trypan blue; Cell; Cell culture; Chemistry; Biochemistry; Antioxidant; Cell biology; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001008363,0.0001755453,0.0001854502,0.0001065648,0.0001385341,0.0001611289,0.00005934472,0.0001931644,0.001196976],"category_scores_gemma":[0.0001605726,0.0000619897,0.0001110955,0.0001316327,0.0001824576,0.0001515415,0.0001072357,0.0003233215,0.0001679761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001201993,"about_ca_system_score_gemma":0.0001339706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001164305,"about_ca_topic_score_gemma":0.000702246,"domain_scores_codex":[0.9999117,0.00001614913,0.000007738984,0.00001972637,0.00002514145,0.00001956814],"domain_scores_gemma":[0.9999343,0.00001830634,0.00001474432,0.000007619,0.00001021203,0.00001469408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001560725,0.0000122385,0.0001128715,0.00002556356,0.000002555124,0.00003800306,0.00002911223,0.00002937419,0.9988422,0.00001937419,0.00002183219,0.0007107934],"study_design_scores_gemma":[0.00001244142,0.0003855603,0.003874589,0.000002806036,0.000009421069,0.0001700976,0.00003686215,0.0002142987,0.9942254,0.00001188613,0.00105359,0.000003040275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965761,0.001474045,0.0007141057,0.00006735662,0.00001844204,0.00001562776,0.0003151378,0.00002139278,0.0007977258],"genre_scores_gemma":[0.9964148,0.000577258,0.000980694,0.00001948207,0.000003875068,0.00002402724,0.0006273335,0.00001044871,0.001341946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001196976,"threshold_uncertainty_score":0.0040043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01121814557852151,"score_gpt":0.2217710451130144,"score_spread":0.2105528995344929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}