{"id":"W3039534321","doi":"10.1136/annrheumdis-2020-eular.364","title":"OP0302 IANALUMAB (VAY736), A DUAL MODE OF ACTION BIOLOGIC COMBINING BAFF RECEPTOR INHIBITION WITH B CELL DEPLETION, REACHES PRIMARY ENDPOINT FOR TREATMENT OF PRIMARY SJOGREN'S SYNDROME","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Salivary Gland Disorders and Functions","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Université de Montréal; Mylan","keywords":"Medicine; B-cell activating factor; Clinical endpoint; Internal medicine; Belimumab; Gastroenterology; Rituximab; Surrogate endpoint; Placebo; Clinical trial; Immunology; Antibody; B cell; Pathology; Lymphoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000696514,0.0005838995,0.001425832,0.000339589,0.0002230505,0.0009824538,0.0003729671,0.0006237833,0.005818928],"category_scores_gemma":[0.0005205443,0.0001227316,0.0009474778,0.0002346539,0.0002666764,0.000549596,0.0002507759,0.00171379,0.001814427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005418257,"about_ca_system_score_gemma":0.0006089134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006356694,"about_ca_topic_score_gemma":0.001682448,"domain_scores_codex":[0.9997076,0.00006022666,0.00001747253,0.0000404099,0.00005369103,0.0001204444],"domain_scores_gemma":[0.9996841,0.00006818357,0.00005215536,0.00002780714,0.00003231844,0.000135433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1078919,0.004362695,0.008036738,0.001829698,0.001639869,0.0006621574,0.0001328048,0.001494786,0.13048,0.002030147,0.02427699,0.7171623],"study_design_scores_gemma":[0.1014308,0.2850229,0.1817486,0.001207491,0.006301574,0.01071047,0.0004938644,0.01019588,0.2230708,0.006424959,0.1731429,0.0002498397],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9215729,0.03483563,0.004381703,0.002335328,0.0009401407,0.000483826,0.002851413,0.001470355,0.03112877],"genre_scores_gemma":[0.9836304,0.00345065,0.001385349,0.001147893,0.0001921682,0.0001511602,0.002297158,0.00007056657,0.007674695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005818928,"threshold_uncertainty_score":0.01946628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07702378990611033,"score_gpt":0.2857495258716496,"score_spread":0.2087257359655393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}