{"id":"W3039534321","doi":"10.1136/annrheumdis-2020-eular.364","title":"OP0302 IANALUMAB (VAY736), A DUAL MODE OF ACTION BIOLOGIC COMBINING BAFF RECEPTOR INHIBITION WITH B CELL DEPLETION, REACHES PRIMARY ENDPOINT FOR TREATMENT OF PRIMARY SJOGREN'S SYNDROME","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Salivary Gland Disorders and Functions","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Université de Montréal; Mylan","keywords":"Medicine; B-cell activating factor; Clinical endpoint; Internal medicine; Belimumab; Gastroenterology; Rituximab; Surrogate endpoint; Placebo; Clinical trial; Immunology; Antibody; B cell; Pathology; Lymphoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006839386,0.0001698351,0.0005898615,0.00007482586,0.00006989589,0.000005753934,0.00005779591,0.00005229466,0.00006836241],"category_scores_gemma":[0.0001054954,0.0001027595,0.0002863375,0.0001998042,0.0001376331,0.00008772439,0.00002572736,0.00003192123,0.000001609303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000307441,"about_ca_system_score_gemma":0.0001727312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007942367,"about_ca_topic_score_gemma":0.000002864872,"domain_scores_codex":[0.9988887,0.00007157076,0.000456803,0.0001995984,0.0002334683,0.0001498368],"domain_scores_gemma":[0.9988672,0.000186951,0.0004312487,0.0002566082,0.0001499619,0.0001080008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09286542,0.06803783,0.3511699,0.0675633,0.01286712,0.000064891,0.02502891,0.008851532,0.09730302,0.002641561,0.06637915,0.2072274],"study_design_scores_gemma":[0.03542138,0.05164361,0.7875238,0.007512724,0.006573388,0.0001392155,0.01218576,0.005174533,0.08336434,0.008182961,0.0009137618,0.001364494],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940986,0.001251854,0.0007605617,0.002169538,0.00005550107,0.0008659592,0.0004755912,0.00003519856,0.0002871722],"genre_scores_gemma":[0.997699,0.000745602,0.0006453564,0.0002315441,0.00001901938,0.00009046096,0.0005000147,0.00001847877,0.00005054789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.436354,"threshold_uncertainty_score":0.419041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07702378990611033,"score_gpt":0.2857495258716496,"score_spread":0.2087257359655393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}