{"id":"W3039735037","doi":"10.1016/j.stemcr.2020.06.003","title":"Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome","year":2020,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Natural Science Foundation of Zhejiang Province; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre; Faculty of Dentistry, McGill University; University of California, Los Angeles; Massachusetts Institute of Technology","keywords":"Biology; Transcriptome; Embryonic stem cell; Trophoblast; DNA methylation; Stem cell; Cell biology; Computational biology; Genetics; Gene; Fetus; Placenta; Gene expression; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254182,0.0002010686,0.0001308395,0.00008830082,0.0000932436,0.000285543,0.0001214009,0.0001653553,0.002034465],"category_scores_gemma":[0.0001549265,0.0001402911,0.0001238959,0.00007299091,0.0002239543,0.0001493637,0.000148776,0.0002504049,0.0004921676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001144329,"about_ca_system_score_gemma":0.0001433581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005055146,"about_ca_topic_score_gemma":0.0007240184,"domain_scores_codex":[0.9999182,0.00001404559,0.00001088819,0.00001805974,0.00003126085,0.000007645532],"domain_scores_gemma":[0.9999352,0.00001492728,0.00001270068,0.0000170796,0.000008795522,0.00001126738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006624973,0.00001097369,0.001124305,0.00004952062,0.000007008229,0.0001274176,0.00006263737,0.0002787492,0.9924109,0.00114319,0.0001417269,0.004577381],"study_design_scores_gemma":[0.0000142456,0.0002377014,0.007044685,0.00001494263,0.0000207013,0.00068962,0.00008618866,0.001673207,0.967315,0.0008870457,0.02200439,0.00001206467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9552881,0.001647968,0.02742873,0.0001644195,0.0001057902,0.000118119,0.002682858,0.0004645578,0.01209943],"genre_scores_gemma":[0.9721337,0.001384821,0.01355384,0.00007693965,0.00001674734,0.00008329035,0.002533393,0.00003541433,0.01018173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002034465,"threshold_uncertainty_score":0.006805956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01254173038140497,"score_gpt":0.2336421952483778,"score_spread":0.2211004648669729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}