{"id":"W3039765753","doi":"10.1158/1557-3265.ovca19-a74","title":"Abstract A74: The HIV protease inhibitor nelfinavir, alone or in combination with the proteasome inhibitor bortezomib, is cytotoxic to high-grade serous ovarian cancer cells regardless of platinum sensitivity","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Bortezomib; Unfolded protein response; Nelfinavir; Proteasome inhibitor; Proteasome; Cancer research; Medicine; Pharmacology; Ovarian cancer; Cancer; Multiple myeloma; Immunology; Endoplasmic reticulum; Biology; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008624654,0.0002853631,0.0003031384,0.0002000396,0.0001689383,0.0002054838,0.0001832378,0.0002511904,0.002530006],"category_scores_gemma":[0.0000961135,0.00008232058,0.0002181796,0.0002252481,0.0001245222,0.0001497638,0.0001206431,0.0003673816,0.000322921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001780123,"about_ca_system_score_gemma":0.0002277278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006699085,"about_ca_topic_score_gemma":0.001061578,"domain_scores_codex":[0.9998868,0.00002232728,0.00001492087,0.00001960761,0.00003028441,0.00002613574],"domain_scores_gemma":[0.9999454,0.00001125575,0.000009499646,0.00000749114,0.000008000206,0.00001829289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001220012,0.0003175834,0.0007088518,0.0001386595,0.00002612177,0.0001032264,0.000021919,0.0001585657,0.9887489,0.0000957599,0.0003805738,0.008079727],"study_design_scores_gemma":[0.0001480686,0.003532587,0.00609205,0.00001190495,0.00003903761,0.0004301271,0.00002543074,0.0006439041,0.9846015,0.00003489129,0.004435268,0.000005164233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919724,0.004446246,0.0004768579,0.00009597339,0.00009445573,0.0000470833,0.0005234607,0.00006734192,0.002276174],"genre_scores_gemma":[0.9952278,0.001181273,0.0007358061,0.00003730701,0.00001687487,0.00003022407,0.0007418278,0.000006478648,0.002022396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002530006,"threshold_uncertainty_score":0.00846374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.112905617212374,"score_gpt":0.408911703047702,"score_spread":0.296006085835328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}