{"id":"W3039818129","doi":"10.1017/s1431927600033869","title":"Insulin Receptor: Structure Via 3D EM Reconstruction, Crystallography and NMR Reveals Details of Ligand Binding and Mechanism of Transmembrane Signalling","year":2000,"lang":"en","type":"article","venue":"Microscopy and Microanalysis","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Icosahedral symmetry; Macromolecule; Crystallography; Symmetry (geometry); Molecule; Electron microscope; Chemical physics; Single particle analysis; Noise (video); Molecular physics; Ligand (biochemistry); Biophysics; Materials science; Chemistry; Physics; Optics; Receptor; Computer science; Biology; Mathematics; Biochemistry; Image (mathematics); Artificial intelligence; Quantum mechanics; Geometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002401061,0.0001801963,0.0001751291,0.0002262738,0.000159367,0.0005347752,0.0002858851,0.0004461059,0.001273356],"category_scores_gemma":[0.0003335703,0.0001625466,0.0001728457,0.0001839415,0.0002880119,0.0003030681,0.0002444203,0.0004284312,0.0006766426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002507886,"about_ca_system_score_gemma":0.0001699977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006558938,"about_ca_topic_score_gemma":0.0008864825,"domain_scores_codex":[0.9999478,0.00001218963,0.000002230826,0.000008619523,0.00002384586,0.000005257179],"domain_scores_gemma":[0.9999436,0.00001326861,0.00001337967,0.00001199572,0.000009239427,0.000008465372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002451805,0.0000439232,0.001311502,0.0001793726,0.00002530677,0.000221037,0.00007340588,0.01723283,0.9547928,0.002894501,0.002267745,0.02071256],"study_design_scores_gemma":[0.00008042447,0.0001234982,0.01532907,0.00005753376,0.00004641925,0.001594888,0.0001693178,0.4212413,0.5333782,0.003048839,0.02488152,0.00004899358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7991528,0.002923664,0.185628,0.001610467,0.0001164327,0.00004242616,0.0009449014,0.001737089,0.007844225],"genre_scores_gemma":[0.8660958,0.002569584,0.1254164,0.0001385028,0.00003231601,0.00002670275,0.001398656,0.0003755106,0.003946609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001273356,"threshold_uncertainty_score":0.004259825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00322069355947217,"score_gpt":0.2051073797970257,"score_spread":0.2018866862375535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}