{"id":"W3039823791","doi":"10.1016/j.jacc.2020.05.027","title":"Efficacy and Safety of Alirocumab in Adults With Homozygous Familial Hypercholesterolemia","year":2020,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"Regeneron Pharmaceuticals","keywords":"Medicine; Familial hypercholesterolemia; Alirocumab; Ldl cholesterol; Internal medicine; Cholesterol; Total cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004252407,0.0001151393,0.001325284,0.00008210271,0.00002180558,0.000001023053,0.0001571461,0.00004750841,0.000001255869],"category_scores_gemma":[0.0001760895,0.00006690658,0.0002797017,0.0003595314,0.0004366245,0.00002919952,0.00006358343,0.000329124,1.969861e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004750797,"about_ca_system_score_gemma":0.0003009274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006126521,"about_ca_topic_score_gemma":0.000009144685,"domain_scores_codex":[0.9985219,0.0002997381,0.0005470673,0.0001318251,0.0003396674,0.0001597683],"domain_scores_gemma":[0.9988155,0.00008482282,0.0005305768,0.0002648177,0.0001726313,0.0001316822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.207209,0.0004658031,0.6229658,0.002222659,0.006496793,0.005840953,0.003534576,0.005570859,0.0220309,0.0002752308,0.002815726,0.1205717],"study_design_scores_gemma":[0.01743565,0.008749881,0.9559038,0.0006633181,0.0004927152,0.009336622,0.002065882,0.00004005948,0.0007656097,0.00001605855,0.004391876,0.0001385065],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956073,0.0007166926,0.0001633292,0.00280604,0.00005892105,0.000338295,0.00002818923,0.000002642593,0.0002786357],"genre_scores_gemma":[0.9978899,0.0006820634,0.0006131433,0.0004982699,0.0002949815,0.000001826337,4.351191e-7,0.00001369148,0.00000563299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.332938,"threshold_uncertainty_score":0.2728371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008782707180646472,"score_gpt":0.2390377106088063,"score_spread":0.2302550034281598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}