{"id":"W3039823791","doi":"10.1016/j.jacc.2020.05.027","title":"Efficacy and Safety of Alirocumab in Adults With Homozygous Familial Hypercholesterolemia","year":2020,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":165,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"Regeneron Pharmaceuticals","keywords":"Medicine; Familial hypercholesterolemia; Alirocumab; Ldl cholesterol; Internal medicine; Cholesterol; Total cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008280207,0.0004260068,0.001107248,0.000295727,0.000365373,0.0006821826,0.0001779999,0.0005970678,0.0007698265],"category_scores_gemma":[0.001618769,0.0001699789,0.0009924609,0.0002410064,0.0002503898,0.0004789757,0.0001520973,0.000960572,0.0001916996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006192954,"about_ca_system_score_gemma":0.000337161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00102645,"about_ca_topic_score_gemma":0.001738631,"domain_scores_codex":[0.9996231,0.0001122105,0.0000522217,0.00006857889,0.00006449103,0.00007950959],"domain_scores_gemma":[0.99937,0.0001993397,0.0001802163,0.00004592038,0.0000829381,0.0001215986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3974668,0.005527114,0.2630992,0.001181294,0.0061771,0.001214377,0.000499375,0.00157748,0.02756091,0.0003735074,0.00326923,0.2920535],"study_design_scores_gemma":[0.05081491,0.09247448,0.8236445,0.0003070964,0.01074496,0.002430634,0.0004657549,0.004846035,0.007377062,0.0005437679,0.006229601,0.0001211118],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927401,0.005423793,0.00009764749,0.0002811552,0.00005757308,0.0000274792,0.0001379303,0.00001899403,0.001215367],"genre_scores_gemma":[0.9983767,0.0007760767,0.00009337148,0.00027478,0.00009434445,0.00001754919,0.0001494955,0.000002848703,0.0002146736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001107248,"threshold_uncertainty_score":0.004493296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008782707180646472,"score_gpt":0.2390377106088063,"score_spread":0.2302550034281598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}