{"id":"W3039842161","doi":"10.1093/nar/gkaa520","title":"Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Max-Planck-Gesellschaft; King Abdullah University of Science and Technology; National Institutes of Health; Ontario Ministry of Research, Innovation and Science; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; Wellcome Trust; National Cancer Institute; AbbVie; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Argonne National Laboratory; Meso Scale Diagnostics; European Commission; Pfizer; Fundação de Amparo à Pesquisa do Estado de São Paulo; Boehringer Ingelheim","keywords":"Biology; Allosteric regulation; Chromatin; Nucleosome; Histone; RNA splicing; Cell biology; Linker; Histone code; Plasma protein binding; Linker DNA; Biochemistry; DNA; Enzyme; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100371,0.0001184432,0.0001009598,0.00005293174,0.00006878182,0.0001764873,0.0001619046,0.0001709075,0.0008883076],"category_scores_gemma":[0.0001456174,0.00007036309,0.0001436814,0.0000540045,0.0001841867,0.0001279937,0.0001645608,0.0001887233,0.0002029183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667192,"about_ca_system_score_gemma":0.00006491447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002139341,"about_ca_topic_score_gemma":0.0002813441,"domain_scores_codex":[0.9999045,0.00001683487,0.00000455278,0.00002784348,0.00002375352,0.00002260058],"domain_scores_gemma":[0.9999249,0.0000155111,0.00002831334,0.00001000855,0.000007008625,0.00001420943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000491578,0.000004382147,0.0002914961,0.000006267469,0.000001906018,0.0000223912,0.000007850304,0.00007088234,0.9988124,0.0001312827,0.000007564244,0.0005943427],"study_design_scores_gemma":[0.00001973005,0.0001096415,0.01568089,0.000004205467,0.00001022496,0.0003174078,0.00003576294,0.003038261,0.9791111,0.0001583428,0.001506975,0.000007307709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980488,0.00026085,0.001115036,0.00001893424,0.000005206624,0.000002168929,0.00002995068,0.00001732907,0.0005017331],"genre_scores_gemma":[0.9992613,0.00007528553,0.0003464945,0.00001250513,0.000001963276,0.000002546677,0.00004396084,0.000005447963,0.0002504526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008883076,"threshold_uncertainty_score":0.002971709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04201181835297191,"score_gpt":0.3237329008729067,"score_spread":0.2817210825199348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}