{"id":"W3039842161","doi":"10.1093/nar/gkaa520","title":"Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Max-Planck-Gesellschaft; King Abdullah University of Science and Technology; National Institutes of Health; Ontario Ministry of Research, Innovation and Science; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; Wellcome Trust; National Cancer Institute; AbbVie; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Argonne National Laboratory; Meso Scale Diagnostics; European Commission; Pfizer; Fundação de Amparo à Pesquisa do Estado de São Paulo; Boehringer Ingelheim","keywords":"Biology; Allosteric regulation; Chromatin; Nucleosome; Histone; RNA splicing; Cell biology; Linker; Histone code; Plasma protein binding; Linker DNA; Biochemistry; DNA; Enzyme; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004343532,0.00008614246,0.0001037842,0.00005626511,0.0001341789,0.00002921083,0.0001775758,0.00009615282,0.0000322761],"category_scores_gemma":[0.0001419939,0.00006993045,0.00003604773,0.0002843013,0.0001815344,0.000007993694,0.0002437285,0.0001531251,0.00001036466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002899128,"about_ca_system_score_gemma":0.00004168874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000606859,"about_ca_topic_score_gemma":0.000009052997,"domain_scores_codex":[0.9988535,0.0001600788,0.0001820183,0.0002792297,0.0003241034,0.0002010758],"domain_scores_gemma":[0.9994507,0.00003190898,0.00007688798,0.0002328408,0.0001424914,0.00006514662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008519806,0.000006789274,0.0008046305,0.00002970582,0.00003741796,4.858306e-7,0.0005024883,0.001028922,0.9879189,0.0001021449,0.0004063435,0.009076999],"study_design_scores_gemma":[0.0007753496,0.0006544709,0.02626421,0.00006304786,0.00001573813,0.00001136809,0.0003415721,0.07070614,0.8975446,0.0003756554,0.003079522,0.0001683854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965318,0.0002952863,0.0009376123,0.001308378,0.00003546899,0.0002754124,0.000006916924,0.000007957918,0.0006012072],"genre_scores_gemma":[0.9990439,0.000138465,0.0003002043,0.00004286127,0.0002385865,0.000009832618,0.00002750373,0.00002122683,0.0001774618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09037433,"threshold_uncertainty_score":0.2851681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04201181835297191,"score_gpt":0.3237329008729067,"score_spread":0.2817210825199348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}