{"id":"W3039842961","doi":"10.1159/000508628","title":"Implementation of PD-L1 22C3 IHC pharmDx<sup>TM</sup> in Cell Block Preparations of Lung Cancer: Concordance with Surgical Resections and Technical Validation of CytoLyt® Prefixation","year":2020,"lang":"en","type":"article","venue":"Acta Cytologica","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Medicine; Concordance; Lung cancer; Cytology; Intraclass correlation; Pembrolizumab; Nuclear medicine; Cancer; Pathology; Internal medicine; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008700619,0.000465631,0.0003225936,0.0008908143,0.0005896754,0.0007992336,0.0007186274,0.0004666414,0.001915652],"category_scores_gemma":[0.008991676,0.0003812056,0.0002464983,0.000539906,0.00106156,0.0003984668,0.001138767,0.0005907019,0.001085936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008027156,"about_ca_system_score_gemma":0.001021411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001832018,"about_ca_topic_score_gemma":0.003734136,"domain_scores_codex":[0.9941659,0.00175444,0.0006979081,0.001369153,0.001688132,0.000324398],"domain_scores_gemma":[0.9904418,0.002981062,0.001570438,0.002440374,0.002271611,0.0002946239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001893176,0.0001949621,0.1591266,0.0003355421,0.0000700871,0.0005654445,0.001655287,0.0007182924,0.7876237,0.0004083459,0.0005739807,0.0468347],"study_design_scores_gemma":[0.00006751251,0.001613306,0.1852742,0.00006899604,0.0001321303,0.002891112,0.000580602,0.007658506,0.7960551,0.0001862826,0.005431029,0.00004121517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9235464,0.0007969165,0.07035043,0.0001358328,0.0000451511,0.0008602964,0.0004080827,0.0005481124,0.00330878],"genre_scores_gemma":[0.9142939,0.0003014631,0.08302663,0.00007173363,0.00001508617,0.0006030294,0.0007916765,0.0001826523,0.0007139188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008700619,"threshold_uncertainty_score":0.04601383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02202138925938156,"score_gpt":0.3282282079863171,"score_spread":0.3062068187269355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}