{"id":"W3039842961","doi":"10.1159/000508628","title":"Implementation of PD-L1 22C3 IHC pharmDx<sup>TM</sup> in Cell Block Preparations of Lung Cancer: Concordance with Surgical Resections and Technical Validation of CytoLyt® Prefixation","year":2020,"lang":"en","type":"article","venue":"Acta Cytologica","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Medicine; Concordance; Lung cancer; Cytology; Intraclass correlation; Pembrolizumab; Nuclear medicine; Cancer; Pathology; Internal medicine; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002522397,0.0001697896,0.0004772298,0.0001325725,0.00006315331,0.000008876633,0.0001071268,0.0001358917,0.0002287806],"category_scores_gemma":[0.00005481427,0.0001378208,0.00008202421,0.0006633757,0.0002278133,0.0001641775,0.00004255808,0.0001573596,3.634537e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001061053,"about_ca_system_score_gemma":0.0002436548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000372217,"about_ca_topic_score_gemma":0.0004335237,"domain_scores_codex":[0.9982854,0.0001265106,0.0007319411,0.0003484691,0.000316877,0.0001908612],"domain_scores_gemma":[0.9988163,0.0001801252,0.0005040349,0.0002175321,0.0002079568,0.00007412777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006319874,0.0003502969,0.1549629,0.0003802722,0.0001535631,0.00001038131,0.001252153,0.000260451,0.8340853,0.0001073685,0.001205886,0.0009114961],"study_design_scores_gemma":[0.01100935,0.003543401,0.2813137,0.0003150815,0.0004290788,0.0001196371,0.000793234,0.001736437,0.697121,0.00002959219,0.003266516,0.0003229722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954429,0.0007222691,0.0001511713,0.001619542,0.0000267145,0.001042508,0.0001122896,0.00003721376,0.0008454509],"genre_scores_gemma":[0.9977461,0.001157052,0.0006919805,0.00006758208,0.00004595736,0.0001399134,0.00010137,0.00001388359,0.00003618333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1369643,"threshold_uncertainty_score":0.5620169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02202138925938156,"score_gpt":0.3282282079863171,"score_spread":0.3062068187269355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}