{"id":"W3039906596","doi":"10.1101/gad.338178.120","title":"A role for alternative splicing in circadian control of exocytosis and glucose homeostasis","year":2020,"lang":"en","type":"article","venue":"Genes & Development","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Diabetes Research and Training Center; Manpei Suzuki Diabetes Foundation; National Institute on Aging; Chicago Biomedical Consortium; Juvenile Diabetes Research Foundation United States of America; National Science Foundation; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Li Ka Shing Foundation; University of Chicago; Harvard University; National Institutes of Health","keywords":"Biology; Alternative splicing; Circadian clock; Cell biology; Exon; Glucose homeostasis; Splicing factor; RNA splicing; Circadian rhythm; CLOCK; Genetics; Gene; RNA; Endocrinology; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010505,0.00008759132,0.000276869,0.00007731574,0.0000244265,0.000005245811,0.00002935837,0.00003075115,0.00002657469],"category_scores_gemma":[0.00009511545,0.00007890703,0.00002807423,0.0001044885,0.00001905392,0.00002374449,0.00001697687,0.00003256799,0.000005202981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004557678,"about_ca_system_score_gemma":0.0001149963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002976724,"about_ca_topic_score_gemma":0.000009900873,"domain_scores_codex":[0.9993532,0.00001189148,0.0002237359,0.0001661598,0.00009987313,0.000145161],"domain_scores_gemma":[0.9996369,0.00007709651,0.00005370059,0.00005589694,0.00004974953,0.0001266149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008506202,0.000123829,0.194299,0.0004453459,0.0003562707,0.00001001289,0.01178528,0.00004262368,0.2365084,0.0001852823,0.0001545338,0.5552388],"study_design_scores_gemma":[0.007951814,0.0003215861,0.2257948,0.0001772374,0.00009841032,0.000004476225,0.00171894,0.002715717,0.7437401,0.00009271235,0.01718271,0.0002014941],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925188,0.004108174,0.001813933,0.0008485232,0.00003027838,0.0004353678,0.000008820724,0.00001386407,0.0002222726],"genre_scores_gemma":[0.9927598,0.0002364149,0.005441009,0.001394884,0.00004051073,0.00008640231,0.00001100832,0.000009442546,0.00002056552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5550373,"threshold_uncertainty_score":0.3217735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02251414594151317,"score_gpt":0.2470020782041514,"score_spread":0.2244879322626382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}