{"id":"W3039906596","doi":"10.1101/gad.338178.120","title":"A role for alternative splicing in circadian control of exocytosis and glucose homeostasis","year":2020,"lang":"en","type":"article","venue":"Genes & Development","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Diabetes Research and Training Center; Manpei Suzuki Diabetes Foundation; National Institute on Aging; Chicago Biomedical Consortium; Juvenile Diabetes Research Foundation United States of America; National Science Foundation; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Li Ka Shing Foundation; University of Chicago; Harvard University; National Institutes of Health","keywords":"Biology; Alternative splicing; Circadian clock; Cell biology; Exon; Glucose homeostasis; Splicing factor; RNA splicing; Circadian rhythm; CLOCK; Genetics; Gene; RNA; Endocrinology; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001411274,0.0001747932,0.0001376974,0.0001750075,0.0001562615,0.0004042733,0.0001894152,0.0001545236,0.0005556557],"category_scores_gemma":[0.0001551412,0.00007864498,0.0001610082,0.0001308081,0.0002646279,0.0002435134,0.000230295,0.0002259937,0.0001382404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000188346,"about_ca_system_score_gemma":0.0001535735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001919998,"about_ca_topic_score_gemma":0.0003195662,"domain_scores_codex":[0.9999126,0.00001159509,0.000007862212,0.00002911721,0.00002310511,0.00001561966],"domain_scores_gemma":[0.9998386,0.0000250853,0.00006254842,0.00002081734,0.00001931245,0.00003360413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001347244,0.00001004687,0.002540491,0.00002530332,0.000008936358,0.0001738652,0.00002814124,0.000142389,0.9908195,0.001035696,0.00003805946,0.005042737],"study_design_scores_gemma":[0.00003491733,0.0005128168,0.12348,0.00002936052,0.00005712072,0.002879695,0.0002338519,0.006571721,0.8496755,0.005746752,0.01074779,0.00003042408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734743,0.00518628,0.01911596,0.0002206323,0.00006260454,0.00001128385,0.000178912,0.0001197551,0.001630307],"genre_scores_gemma":[0.9935783,0.001455542,0.003969396,0.00006212734,0.00002968777,0.000006434368,0.000138586,0.00001808103,0.0007417682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005556557,"threshold_uncertainty_score":0.00185889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02251414594151317,"score_gpt":0.2470020782041514,"score_spread":0.2244879322626382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}